Citations 1
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Kunz, Hawley , Hart, Corey R., Gries, Kevin J. , Parvizi, Mojtaba, LAURENTI, MARCELLO C. , Man, Chiara Dalla , Moore, Natalie , Zhang, Xiaoyan , Ryan, Zachary, Jensen, Michael D. , Kunz, Hawley E., Laurenti, Marcello, Dalla Man, Chiara , Jensen, Michael , Vella, Adrian , Lanza, Ian R , Kunz, Hawley E , Polley, Eric C. , Vella, Adrian , Lanza, Ian R.
American Journal of Physiology-Endocrinology and Metabolism | May 17, 2021 | Volume: 321 | Issue: 1 | Pages: E105-E121
Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity. The present study provides evidence to support adipose inflammation as a central feature of the pathophysiology of obesity. Adipose inflammation is associated with systemic and peripheral metabolic derangements, including increased systemic inflammation, reduced insulin sensitivity and reduced skeletal muscle mitochondrial respiration.