Back to Authors

Cairns, Nigel J.

https://orcid.org/0000-0001-9858-3344

Mayo Clinic

for the ADNI, ALFA, and PREVENT-AD Study Groups

Citations 44

O2‐06‐01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study
Chhatwal, Jasmeer P. , Johnson, Keith A. , Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Xiong, Chengjie , Moulder, Krista L., Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , Mathis, Chester A. , Goate, Alison , Masters, Colin L. , Ghetti, Bernardino , Martins, Ralph N. , Bateman, Randall J. , Morris, John C. , Sperling, Reisa Anne

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available

10.1016/j.jalz.2012.05.654 Get It

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Phelps, Creighton H., Beach, Thomas G. , Bigio, Eileen H. , Cairns, Nigel J. , Carrillo, María C. , Dickson, Dennis W. , Duyckaerts, Charles , Frosch, Matthew P. , Masliah, Eliezer , Mirra, Suzanne S., Nelson, Peter T. , Thal, Dietmar Rudolf , Thies, Bill, Trojanowski, John Q. , Vinters, Harry V. , Montine, Thomas J. , Hyman, Bradley T. , Schneider, Julie A. , Dickson, Dennis W , Thal, Dietmar Rudolf

Alzheimer's & Dementia | January 19, 2012 | Volume: 8 | Issue: 1 | Pages: 1-13

10.1016/j.jalz.2011.10.007 Get It

Abstract A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre‐clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP‐43 inclusions, and recommend standard approaches for the workup of cases and their clinico‐pathologic correlation.
The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans
Weiner, Michael W. , Aisen, Paul , Jack, Clifford R. , Jagust, William J. , Trojanowski, John Q. , Shaw, Leslie M. , Saykin, Andrew J. , Morris, John C. , Cairns, Nigel J. , Beckett, Laurel , Walter, Sarah , Soares, Holly , Snyder, Peter J. , Siemers, Eric , Potter, William Z., Cole, Patricia E., Initiative, Alzheimer's Disease Neuroimaging, Toga, Arthur W. , Green, Robert C. , Schmidt, Mark E. , Initiative, Alzheimer's Disease Neuroimaging, Jack, Clifford R , Saykin, Andrew J , Morris, John C

Alzheimer's & Dementia | May 7, 2010 | Volume: 6 | Issue: 3 | Pages: 202

10.1016/j.jalz.2010.03.007 Get It

The Alzheimer's Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6‐year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer's disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C‐11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid β (Aβ) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C‐11 Pittsburgh compound B PET, and CSF measurements of Aβ and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI‐like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.
P3‐287: TDP‐43 A315T mutation in familial motor neuron disease
Baloh, Robert H. , Chakraverty, Sumi, Mayo, Kevin, Norton, Joanne, Levitch, Denise, Hatanpaa, Kimmo J. , White, Charles H., Bigio, Eileen H. , Caselli, Richard J. , Baker, Matt , Al‐Lozi, Muhammad, Pestronk, Alan , Rademakers, Rosa , Cairns, Nigel J. , Gitcho, Michael A. , Morris, John C. , Goate, Alison

Alzheimer's & Dementia | July 24, 2008 | Volume: 4 | Issue: 4S_Part_18 | Pages: No page available

10.1016/j.jalz.2008.05.1855 Get It