Citations 2
Dominant‐negative CARD11 loss‐of‐function variant presenting with hypereosinophilic syndrome
Wilson, Bridget E. , Stechelman, Payge Van, Mariani, R , Goswami, Nikita, Sidebottom, Nicole, Bauer, Cindy S. , Mariani, Rachel , Stechelman, Payge Van , Sacco, Keith
Pediatric Allergy and Immunology | November 21, 2023 | Volume: 34 | Issue: 11 | Pages: No page available
EBV-Positive Plasmacytomas Involving a Nasopharyngeal Angiofibroma in an Adolescent
Mariani, R , King, Rebecca L. , Liu, Huifei , Mariani, Rachel
Pediatric and Developmental Pathology | March 8, 2021 | Volume: 24 | Issue: 3 | Pages: 264-268
We report comprehensive characterization of an unusual collision tumor comprising extramedullary plasmacytomas and nasopharyngeal angiofibroma in a pediatric patient, which has yet to be reported. Histologically, the nasopharyngeal angiofibroma showed typical morphology with a diffuse, dense plasmacytic infiltrate in the stroma. The neoplastic plasma cells showed a spectrum of well-differentiated, plasmablastic, and anaplastic morphology, Epstein-Barr virus encoded RNA (EBER) positivity, and aberrant immunophenotype. Fluorescence in situ hybridization using a plasma cell myeloma targeted panel detected gains of 1q21.3 ( CKS1B, x3), 3q27 ( BCL6, x4), and 11q22.3 ( ATM, x3), but no rearrangement of ALK and MYC. A 50-gene next generation sequencing lymphoma panel failed to detect any pathogenic mutation. Plasmacytoma with EBER positivity and plasmablastic morphology must be distinguished from plasmablastic lymphoma due to different clinical management and prognosis. This case highlights the importance of a thorough pathological evaluation of a mass lesion with synchronous neoplastic processes.