Citations 59
The Impact of Health Information Technology for Early Detection of Patient Deterioration on Mortality and Length of Stay in the Hospital Acute Care Setting: Systematic Review and Meta-Analysis
Lipatov, Kirill , Pinevich, Yuliya , Tekin, Aysun , Pickering, Brian W. , Barwise, Amelia , Herasevich, Svetlana , Lindroth, Heidi , Barwise, Amelia K , Tekin, Aysun , Herasevich, Vitaly
Critical Care Medicine | April 12, 2022 | Volume: No volume available | Issue: No issue available | Pages: No page available
Objective: To evaluate the impact of health information technology (HIT) for early detection of patient deterioration on patient mortality and length of stay (LOS) in acute care hospital settings. Data Sources: We searched MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus from 1990 to January 19, 2021. Study Selection: We included studies that enrolled patients hospitalized on the floor, in the ICU, or admitted through the emergency department. Eligible studies compared HIT for early detection of patient deterioration with usual care and reported at least one end point of interest: hospital or ICU LOS or mortality at any time point. Data Extraction: Study data were abstracted by two independent reviewers using a standardized data extraction form. Data Synthesis: Random-effects meta-analysis was used to pool data. Among the 30 eligible studies, seven were randomized controlled trials (RCTs) and 23 were pre-post studies. Compared with usual care, HIT for early detection of patient deterioration was not associated with a reduction in hospital mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT interventions demonstrated a significant association with improved hospital mortality for the entire study cohort (odds ratio, 0.78 [95% CI, 0.70–0.87]) and reduced hospital LOS overall. Conclusions: HIT for early detection of patient deterioration in acute care settings was not significantly associated with improved mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT was associated with improved hospital mortality and LOS; however, these results should be interpreted with caution. The differences in patient outcomes between the findings of the RCTs and pre-post studies may be secondary to confounding caused by unmeasured improvements in practice and workflow over time.
Cutaneous manifestations of hospitalized COVID‐19 patients in the VIRUS COVID‐19 registry
Deo, Neha , Tekin, Aysun , Bansal, Vikas , Koritala, Thoyaja , Mullen, Barbara , Armaignac, Donna Lee , Gharpure, Varsha , Bogojevic, Marija , Qamar, Shahraz , Sharma, Mayank , Kumar, Vishakha K. , Domecq, Juan Pablo , Group, From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry Investigator, Singh, Romil , Kumar, Vishakha, Walkey, Allan, Domecq, Juan P, Alavi, A , Bansal, Vikas , Mullen, Barbara L , Gharpure, Varsha P , Deo, Neha N , Tekin, Aysun , Domecq Graces, Juan Pablo , Chiotos, Kathleen , Bjornstad, Erica C. , Gajic, Ognjen , Walkey, Allan J. , Kashyap, Rahul , Alavi, Afsáneh , Group, From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry Investigator
International Journal of Dermatology | February 19, 2022 | Volume: 61 | Issue: 5 | Pages: 623-625
Association of hypothyroidism with outcomes in hospitalized adults with COVID‐19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry
Bogojevic, Marija , Bansal, Vikas , Pattan, Vishwanath , Tekin, Aysun , Sharma, Mayank , Nou, Abigail T. La, Hanson, Andrew C. , Schulte, Phillip J. , Qamar, Shahraz , Morales, Diana J. Valencia , Perkins, Nicholas , Kaufman, Margit, Melamed, Roman , Christie, Amy B. , Tarabichi, Yasir , Heavner, Smith F. , Kumar, Vishakha K. , Bhagra, Sumit , Lal, Amos , Domecq, Juan Pablo , Group, Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry Investigator, Koritala, Thoyaja , Asghar, Muhammad Sohaib , Singh, Romil , La Nou, Abigail T, Zec, Simon , Valencia Morales, Diana J , Denson, Joshua L , Gajic, Ognjen , Kashyap, Rahul , Lal, Amos , Domecq, Juan Pablo , Bansal, Vikas , Asghar, Muhammad S , Tekin, Aysun , Domecq Graces, Juan Pablo , Nou, Abigail La, LeMahieu, Allison , Deo, Neha , Denson, Joshua L. , Banner‐Goodspeed, Valerie , Walkey, Allan J. , Gajic, Ognjen , Kashyap, Rahul , Group, Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry Investigator
Clinical Endocrinology | February 18, 2022 | Volume: 101 | Issue: 1 | Pages: 85-93
AbstractIntroductionCoronavirus disease 2019 (COVID‐19) is associated with high rates of morbidity and mortality. Primary hypothyroidism is a common comorbid condition, but little is known about its association with COVID‐19 severity and outcomes. This study aims to identify the frequency of hypothyroidism in hospitalized patients with COVID‐19 as well as describe the differences in outcomes between patients with and without pre‐existing hypothyroidism using an observational, multinational registry.MethodsIn an observational cohort study we enrolled patients 18 years or older, with laboratory‐confirmed severe acute respiratory syndrome coronavirus‐2 infection between March 2020 and February 2021. The primary outcomes were (1) the disease severity defined as per the World Health Organization Scale for Clinical Improvement, which is an ordinal outcome corresponding with the highest severity level recorded during a patient's index COVID‐19 hospitalization, (2) in‐hospital mortality and (3) hospital‐free days. Secondary outcomes were the rate of intensive care unit (ICU) admission and ICU mortality.ResultsAmong the 20,366 adult patients included in the study, pre‐existing hypothyroidism was identified in 1616 (7.9%). The median age for the Hypothyroidism group was 70 (interquartile range: 59–80) years, and 65% were female and 67% were White. The most common comorbidities were hypertension (68%), diabetes (42%), dyslipidemia (37%) and obesity (28%). After adjusting for age, body mass index, sex, admission date in the quarter year since March 2020, race, smoking history and other comorbid conditions (coronary artery disease, hypertension, diabetes and dyslipidemia), pre‐existing hypothyroidism was not associated with higher odds of severe disease using the World Health Organization disease severity index (odds ratio [OR]: 1.02; 95% confidence interval [CI]: 0.92, 1.13; p = .69), in‐hospital mortality (OR: 1.03; 95% CI: 0.92, 1.15; p = .58) or differences in hospital‐free days (estimated difference 0.01 days; 95% CI: −0.45, 0.47; p = .97). Pre‐existing hypothyroidism was not associated with ICU admission or ICU mortality in unadjusted as well as in adjusted analysis.ConclusionsIn an international registry, hypothyroidism was identified in around 1 of every 12 adult hospitalized patients with COVID‐19. Pre‐existing hypothyroidism in hospitalized patients with COVID‐19 was not associated with higher disease severity or increased risk of mortality or ICU admissions. However, more research on the possible effects of COVID‐19 on the thyroid gland and its function is needed in the future.
Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
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JAMA Network Open | December 22, 2021 | Volume: 4 | Issue: 12 | Pages: e2140568
1267: HEALTH INFORMATION TECHNOLOGY TO DETECT PATIENT DETERIORATION: SYSTEMATIC REVIEW AND META-ANALYSIS
Lipatov, Kirill , Pinevich, Yuliya , Pickering, Brian W. , Herasevich, Svetlana , Lindroth, Heidi , Tekin, Aysun , Herasevich, Vitaly , Barwise, Amelia
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 634-634
269: HOW DO FRONTLINERS LEARN DURING A PANDEMIC? A GLOBAL SURVEY EVALUATING COVID-19 WEBINARS
Qamar, Shahraz , Taji, Jamil, Sharma, Mayank , Bogojevic, Marija , Adhikari, Ramesh , Garces, Juan Pablo Domecq , Tekin, Aysun , Bansal, Vikas , Singh, Romil , Deo, Neha , Surani, Salim , Kashyap, Rahul
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 119-119
218: A CASE OF ADULT MULTISYSTEM INFLAMMATION SYNDROME FOLLOWING COVID-19 VACCINE
Brown, Meghan, Garces, Juan Pablo Domecq , Das, Subhraleena, Muigai, Maureen, Boisseau, Robert, Khan, Syed Anjum , Gajić, Ognjen, Jain, Nitesh , Garbajs, Nika Zorko , Tekin, Aysun , Bansal, Vikas , Gajic, Ognjen
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 93-93
190: ASSOCIATION OF OBESITY AND COVID-19-INDUCED DIARRHEA: RESULTS FROM THE SCCM DISCOVERY VIRUS REGISTRY
Bogojevic, Marija , Nou, Abigail La, Hanson, Andrew C. , Schulte, Phillip J. , Qamar, Shahraz , Kumar, Vishakha K. , Gajić, Ognjen, Garces, Juan Pablo Domecq , Sharma, Mayank Kumar , Tekin, Aysun , Bansal, Vikas , Singh, Romil , LeMahieu, Allison , Deo, Neha , Zec, Simon , Walkey, Allan J. , Kashyap, Rahul, Gajic, Ognjen , Acosta, Andrés
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 79-79
163: DERMATOLOGIC MANIFESTATIONS IN PATIENTS WITH COVID-19: RESULTS FROM THE DISCOVERY VIRUS REGISTRY
Mullen, Barbara , Bogojevic, Marija , Sharma, Mayank , Qamar, Shahraz , Kumar, Vishakha K. , Garces, Juan Pablo Domecq , Deo, Neha , Alavi, Afsáneh , Tekin, Aysun , Bansal, Vikas , Koritala, Thoyaja , Singh, Romil , Zec, Simon , Walkey, Allan J. , Gajic, Ognjen , Kashyap, Rahul
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 65-65
150: ASSOCIATION OF LATITUDE AND ALTITUDE WITH COVID-19 SYMPTOMS: SCCM DISCOVERY VIRUS REGISTRY ANALYSIS
Qamar, Shahraz , Sharma, Mayank , Bogojevic, Marija , Hanson, Andrew C. , Schulte, Phillip J. , Christie, Amy B. , Anderson, Harry, Kumar, Vishakha K. , Garces, Juan Pablo Domecq , Tekin, Aysun , Bansal, Vikas , Singh, Romil , Deo, Neha , LeMahieu, Allison , Sili, Uluhan , Anderson, Harry, Walkey, Allan J. , Gajic, Ognjen , Kashyap, Rahul
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 58-58