Citations 2
Evaluating the current neuro-oncology capacity in Sub-Saharan Africa: A questionnaire-based survey
Odukoya, Lateef A , Cheserem, Beverly , Darko, Kwadwo , Ghomsi, Nathalie , Kabare, Gloria , Kamson, David , Eckel‐Passow, Jeanette E. , Jenkins, Robert B. , Decker, Paul A. , Kitange, Gaspar J. , Akinjo, Andrea O , Badmos, Kabir, Yevudza, W Elorm , Edrick, Elias, Katasi, Victoria Mwebe , Magambo, Margreth, Banti, Eyerusalem, Magoha, Michael, Ngaiza, Advera , Higgins, Dominique, Okemwa, Minda, Osei‐Tutu, Lawrence, Petershie, Bernard, Minja, Frank J. , Anunobi, C C , Tiamiyu, Liadi, Gankpé, Gbètoho Fortuné, Kwikima, Ugumba, Heronima, Kashaigili, Schroeder, Kristin, Thierry, Muanza, Davidson, Alan J. , Totimeh, Teddy , Gankpé, Fortuné Gbètoho , Schroeder, Kristin , Zerd, Francis , Odukoya, Lateef A , Cheserem, Beverly , Darko, Kwadwo , Ghomsi, Nathalie C , Kamson, David O , Eckel-Passow, Jeanette E , Jenkins, RB , Akinjo, Andrea O , Badmos, Kabir B , Yevudza, W Elorm , Bankole, Olufemi , Idowu, Olufemi E , Ayanlaja, Abiola Abdulrahman , Karekezi, Claire , Edrick, Elias , Ekhator, Chukwuyem , Huse, Jason T. , Magoha, Michael , Okemwa, Minda , Minja, Frank J , Etame, Arnold B , Kwikima, Ugumba Mussa , Schroeder, Kristin , Muanza, Thierry , Totimeh, Teddy , Balogun, James , Zerd, Francis , Decker, Paul A. , LLEWELLYN, HENRY J. , Idowu, Olufemi Emmanuel , Karekezi, Claire , Lachance, Daniel Honore , Banti, Eyerusalem, Nyalundja, Arsène Daniel , Etame, Arnold B. , Brown, Desmond , Davidson, Alan, Fonkem, Ekokobe
Neuro-Oncology Practice | October 10, 2025 | Volume: 13 | Issue: 3 | Pages: 537-548
AbstractAbstract Background Central nervous system (CNS) tumors are a significant cause of morbidity and mortality in Sub-Saharan Africa (SSA). This project aimed to assess and map out the current neuro-oncology capacity in SSA, brain tumor registries, and biobanks. Methods This cross-sectional study utilized an online survey to gather data from healthcare professionals involved in CNS tumor care across SSA through the Society for Neuro-Oncology SSA (SNOSSA). The survey captured information on the availability of neuro-oncology practitioners, neuropathology, molecular diagnostics, cancer registries, and biobanking. Results A total of 145 respondents representing 70 healthcare institutions across 22 countries participated. Of the 70 institutions, specialties included neurosurgery (89%, 62/70), anatomic pathology (74%, 52/70), and medical oncology (71%, 50/70). For radiologic evaluation, 64% (45/70) of responding institutions reported having both CT and MRI. Access to molecular testing through immunohistochemistry or next-generation sequencing was available in 46% (32/70) of responding institutions. Multidisciplinary tumor boards were available for CNS cases in 86% (60/70) of responding institutions. Brain tumor-specific registries were available in 29% (20/70) of responding institutions, and 10% (7/70) maintained brain tumor biorepositories. Conclusion This study demonstrates that SSA has substantial potential in neuro-oncology care practice capacity and facilities. The most significant gaps were in neuropathology and molecular testing, which makes widespread implementation of the WHO 2021 diagnosis challenging. Understanding the prevalence of CNS tumor subtypes in SSA is difficult due to the low number of brain tumor registries and biobanks.
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
Li, Bingjue, Zhu, Chaohong, Dong, Lihua , Xiang, Wenyu, Davidson, Alan J. , Feng, Shi , Wang, Yucheng , Shen, Xiujin , Weng, Chunhua , Teng, Lisha, Wang, Junwen , Chen, Jianghua , Jiang, Hong , Chen, Jianghua , Jiang, Hong , Wang, Junwen , Qin, Jing , Wang, Cuili , Zhu, Tingting, Englert, Christoph
The Journal of Pathology | July 27, 2020 | Volume: 252 | Issue: 3 | Pages: 274-289
AbstractDisturbed intrauterine development increases the risk of renal disease. Various studies have reported that Notch signalling plays a significant role in kidney development and kidney diseases. A disintegrin and metalloproteinase domain 10 (ADAM10), an upstream protease of the Notch pathway, is also reportedly involved in renal fibrosis. However, how ADAM10 interacts with the Notch pathway and causes renal fibrosis is not fully understood. In this study, using a prenatal chlorpyrifos (CPF) exposure mouse model, we investigated the role of the ADAM10/Notch axis in kidney development and fibrosis. We found that prenatal CPF‐exposure mice presented overexpression of Adam10, Notch1 and Notch2, and led to premature depletion of Six2+ nephron progenitors and ectopic formation of proximal tubules (PTs) in the embryonic kidney. These abnormal phenotypic changes persisted in mature kidneys due to the continuous activation of ADAM10/Notch and showed aggravated renal fibrosis in adults. Finally, both ADAM10 and NOTCH2 expression were positively correlated with the degree of renal interstitial fibrosis in IgA nephropathy patients, and increased ADAM10 expression was negatively correlated with decreased kidney function evaluated by serum creatinine, cystatin C, and estimated glomerular filtration rate. Regression analysis also indicated that ADAM10 expression was an independent risk factor for fibrosis in IgAN. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.