Citations 1
Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia
Limberg, Jacqueline K. , Smith, James , Soares, Rogério N. , Harper, Jennifer L. , Houghton, K., Jacob, Dain W. , Mozer, Michael T., Grunewald, Zachary I., Johnson, Blair D. , Curry, Timothy B. , Padilla, Jaume , Johnson, Blair D , Padilla, Jaume , Houghton, Keeley N., Baynard, Tracy , Manrique‐Acevedo, Camila
American Journal of Physiology-Heart and Circulatory Physiology | June 5, 2020 | Volume: 319 | Issue: 1 | Pages: H162-H170
We examined the role of sympathetic activation in restraining vasodilatory responses to hyperinsulinemia and sustaining blood pressure in healthy adults. Data are reported from two separate experimental protocols in humans and one experimental protocol in isolated arteries from mice. Contrary to our hypothesis, the present findings support the idea that during hyperinsulinemia, a sympathetically mediated increase in cardiac output, rather than restraint of peripheral vasodilation, is the principal contributor to the maintenance of systemic blood pressure.