Citations 1
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells
Stelzig, Kimberly E. , Canepa-Escaro, Fabrizio, Schiliro, Marta, Berdnikovs, Sergejs , Prakash, Y. S. , Chiarella, Sergio E. , Prakash, Y S , Stelzig, Kimberly E. , Chiarella, Sergio E
American Journal of Physiology-Lung Cellular and Molecular Physiology | May 20, 2020 | Volume: 318 | Issue: 6 | Pages: L1280-L1281
There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.