Citations 2
Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease
Nicholson, Maribeth R. , Alexander, Erin, Ballal, Sonia, Davidovics, Zev, Docktor, Michael , Dole, Michael , Gisser, Jonathan M., Goyal, Alka , Hourigan, Suchitra K. , Jensen, M. Kyle , Kaplan, Jess L. , Kelsen, Judith R. , Khanna, Sahil , Knackstedt, Elizabeth D , Lentine, Jennifer, Lewis, Jeffery D., Michail, Sonia , Mitchell, Paul D. , Patton, Tiffany , Queliza, Karen , Sidhu, Sarah , Solomon, Aliza , Suskind, David L. , Weatherly, Madison, Werlin, Steven L. , Zoeten, Edwin F. de , Kahn, Stacy A. , Group, North American Society of Pediatric Gastroenterology and Nutrition Faecal Microbiota Transplantation Special Interest, Aktay, Nur, Asbah, Imad, Bassett, Mikelle, Brumbaugh, David , Caicedo, Luis A. , Chawla, Anu, Conrad, Máire , Dykes, Chelly Dana, Grzywacz, Kelly, Gulati, Ajay, Gurram, Bhaskar , Hellman, Jenny, Kastl, Art, Mallon, Danny, Pai, Nikhil , Pasternak, Brad , Prozialeck, Josh, Reilly, Norelle R., Russell, George H., Singh, Namita , Small‐Harary, Lesley , Sood, Shilpa , Stumphy, Jessica, Sullivan, Jill M., Syed, Sabeen, Titgemeyer, Cebie, Townsend, Pete, Zheng, Yuhua , Suskind, David L , Alexander, Erin, Kellermayer, Richárd , Kennedy, Melissa A, Oliva‐Hemker, Maria , Group, North American Society of Pediatric Gastroenterology and Nutrition Faecal Microbiota Transplantation Special Interest, Bartlett, Mark, Caicedo, Luis, Gulati, Ajay, Patel, Ashish , Prozialeck, Joshua D. , Sood, Shilpa, Sullivan, Jill
Journal of Crohn's and Colitis | November 8, 2021 | Volume: 16 | Issue: 5 | Pages: 768-777
Abstract Background Children with inflammatory bowel disease [IBD] are disproportionally affected by recurrent Clostridioides difficile infection [rCDI]. Although faecal microbiota transplantation [FMT] has been used with good efficacy in adults with IBD, little is known about outcomes associated with FMT in paediatric IBD. Methods We performed a retrospective review of FMT at 20 paediatric centres in the USA from March 2012 to March 2020. Children with and without IBD were compared with determined differences in the efficacy of FMT for rCDI. In addition, children with IBD with and without a successful outcome were compared with determined predictors of success. Safety data and IBD-specific outcomes were obtained. Results A total of 396 paediatric patients, including 148 with IBD, were included. Children with IBD were no less likely to have a successful first FMT then the non-IBD affected cohort [76% vs 81%, p = 0.17]. Among children with IBD, patients were more likely to have a successful FMT if they received FMT with fresh stool [p = 0.03], were without diarrhoea prior to FMT [p = 0.03], or had a shorter time from rCDI diagnosis until FMT [p = 0.04]. Children with a failed FMT were more likely to have clinically active IBD post-FMT [p = 0.002] and 19 [13%] patients had an IBD-related hospitalisation in the 3-month follow-up. Conclusions Based on the findings from this large US multicentre cohort, the efficacy of FMT for the treatment of rCDI did not differ in children with IBD. Failed FMT among children with IBD was possibly related to the presence of clinically active IBD.
Pulmonary Manifestations in Adolescents With Inflammatory Bowel Disease
Barfield, Elaine, Deshmukh, Farah , Slighton, Elisabeth, Lentine, Jennifer, Lu, Yao , Ma, Xiaoyue , Christos, Paul J. , Sockolow, Robbyn , Loughlin, Gerald M., Pillai, Sophia
Clinical Pediatrics | March 7, 2020 | Volume: 59 | Issue: 6 | Pages: 573-579
Objectives. The available literature on pulmonary disease in pediatric inflammatory bowel disease is limited. We evaluated the prevalence of pulmonary manifestations in pediatric inflammatory bowel disease and their association with disease severity. Methods. Patients completed the St. George’s Respiratory Questionnaire (SGRQ), a self-reported measure of quality of life in patients with pulmonary disease. Chart review provided demographic information and Pediatric Crohn’s Disease Activity Index (PCDAI) and Pediatric Ulcerative Colitis Activity Index scores. Regression models were utilized to evaluate associations between SGRQ score and clinical risk factors. Results. The prevalence of pulmonary manifestations was 9.62% (95% confidence interval = 5.48% to -15.36%). PCDAI scores in Crohn’s disease patients with pulmonary symptoms were significantly higher (SGRQ mean = 10.71 ± 10.94) than in patients without such symptoms. SGRQ score was also higher in patients with indeterminate colitis (8.64, 95% confidence interval = 0.72-16.57, P = .03), when compared with Crohn’s disease. Conclusions. Additional investigations including pulmonary function tests and imaging could provide further insight into this issue.