Citations 79
Combined Pathologies in FTLD-TDP Types A and C
Gefen, Tamar , Mao, Qinwen , Kım, Garam , Seçkin, Mustafa , Bonakdarpour, Borna , Ramos, Eliana Marisa , Coppola, Giovanni , Rademakers, Rosa , Rogalskı, Emily , Rademaker, Alfred , Weıntraub, Sandra , Geula, Changiz , Bigio, Eileen H. , Ahmadian, Saman Seyed , Mesulam, Marsel M. , Mao, Qinwen
Journal of Neuropathology & Experimental Neurology | March 23, 2018 | Volume: 77 | Issue: 5 | Pages: 405-412
Measuring cognition and function in the preclinical stage of Alzheimer's disease
Weıntraub, Sandra , Farias, Sarah Tomaszewski , Goldberg, Terry E. , Hendrix, James A. , Jaeger, Judith , Park, Denise C. , Ropacki, Michael T., Sikkes, Sietske A.M. , Bain, Lisa J. , Brashear, Robert, Budur, Kumar, Graf, Ana, Martényi, Ferenc, Storck, Marta Segardahl, Randolph, Christopher , Carrillo, María C. , Knopman, David S. , Langbaum, Jessica B. S. , Welsh-Bohmer, Kathleen Anne
Alzheimer's & Dementia: Translational Research & Clinical Interventions | February 13, 2018 | Volume: 4 | Issue: 1 | Pages: 64-75
Abstract The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti‐Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed.
[P2–281]: CAREGIVER BURDEN IN FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS: PRELIMINARY DATA IN THE LEFFTDS COHORT
Hughes, Samantha R., Rosen, Howard J. , Boxer, Adam L. , Calvert, Kendrick J., Dheel, Christina, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Heuer, Hilary W. , Huey, Edward D. , Kornak, John , Kraft, Ruth, Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Rankin, Katherine , Syrjanen, Jeremy A. , Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Knopman, David S. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_14 | Pages: No page available
[P2–317]: PHENOCONVERSION FROM ASYMPTOMATIC TO MINIMALLY SYMPTOMATIC FTLD: PRELIMINARY DATA IN THE LEFFTDS COHORT
Rosen, Howard J. , Boxer, Adam L. , Coppola, Giovanni , Dheel, Christina, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Heuer, Hilary W. , Huey, Edward D. , Kornak, John , Kraft, Ruth, Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Phelps, Creighton H., Rademakers, Rosa , Rankin, Katherine , Sutherland, Marg, Syrjanen, Jeremy A. , Taylor, Joanne, Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Knopman, David S. , Kukull, Walter A. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available
[P1–317]: QUALITY OF LIFE AMONG SUBJECTS AND INFORMANTS IN FAMILIAL FRONTOTEMPORAL DEMENTIA: PRELIMINARY DATA IN THE LEFFTDS COHORT
Calvert, Kendrick J., Rosen, Howard J. , Boxer, Adam L. , Dheel, Christina, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Heuer, Hilary W. , Huey, Edward D. , Hughes, Samantha R., Kornak, John , Kraft, Ruth, Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Rankin, Katherine , Syrjanen, Jeremy A. , Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Knopman, David S. , Lapid, Maria I. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_7 | Pages: No page available
[P2–303]: ADVANCING RESEARCH AND TREATMENT IN FRONTOTEMPORAL LOBAR DEGENERATION (ARTFL) NORTH AMERICAN RARE DISEASE CLINICAL RESEARCH CONSORTIUM: PROGRESS AND CHARACTERIZATION OF INITIAL PARTICIPANTS
Boxer, Adam L. , Rosen, Howard J. , Heuer, Hilary W. , Coppola, Giovanni , Bordelon, Yvette , Dheel, Christina, Faber, Kelley , Fields, Julie A. , Ghoshal, Nupur , Graff-Radford, N. R., Huey, Edward D. , Kaufer, Daniel , Karydas, Anna, Kramer, Joel H. , Lungu, Codrin , Mackenzie, Ian R. , Mendez, Mario F. , Miller, Matt R., Onyike, Chiadi U. , Pantelyat, Alex, Potter, Madeline, Rademakers, Rosa , Sutherland, Margaret , Weıntraub, Sandra , Boeve, Bradley F. , Grossman, Murray , Dickerson, Bradford Clark , Fong, Jamie , Foroud, Tatiana , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Knopman, David S. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available
[P1–254]: CHARACTERISTICS AND PROGRESS ON THE INITIAL 209 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL
Dheel, Christina, Rosen, Howard J. , Boxer, Adam L. , Coppola, Giovanni , Faber, Kelley, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff-Radford, N. R., Heuer, Hilary W. , Huey, Edward D. , Karydas, Anna, Kornak, John , Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Phelps, Creighton H., Rademakers, Rosa , Rankin, Katherine , Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Trojanowski, John Q. , Vetor, Ashley, Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Knopman, David S. , Kukull, Walter A. , Miller, Bruce L. , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_7 | Pages: No page available
Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
Jun, Gyungah , Chung, Jaeyoon , Beecham, Gary W. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Carrasquillo, Minerva M., Crane, Paul K. , Cruchaga, Carlos , Jager, Philip L. De , Ertekin‐Taner, Nilüfer , Evans, Denis A., Fallin, M. Danielle, Friedland, Robert P. , Goate, Alison , Graff‐Radford, Neill R. , Hendrie, Hugh C. , Hall, Kathleen, Hamilton‐Nelson, Kara L., Kukull, Walter A. , Kunkle, Brian W. , Kuwano, Ryozo, Larson, Eric B., Martin, Eden R. , Montine, Thomas J. , Reiman, Eric M. , Reitz, Christiane, Sherva, Richard , George‐Hyslop, Peter St , Thornton, Timothy, Younkin, Steven G., Wang, Li‐San , Wendlund, Jens R., Winslow, Ashley R. , Adams, Perrie M. , Albert, Marilyn S. , Albin, Roger L. , Apostolova, Liana G. , Arnold, Steven E. , Asthana, Sanjay , Atwood, Craig , Barmada, Michjael M, Beach, Thomas G. , Bigio, Eileen H. , Bird, Thomas D., Blacker, Deborah , Bowen, James D. , Boxer, Adam, Cairns, Nigel J. , Cao, Chuanhai , Carlson, Chris , Carlsson, Cynthia M., Carney, Regina M., Carroll, Steven L. , Chui, Helena C., Clark, David G., Corneveaux, Jason J., Cribbs, David H. , DeKosky, Steven T. , Demirci, F. Yesim , Dick, Malcolm, Doody, Rachelle S., Duara, Ranjan , Faber, Kelley , Fairchild, Thomas, Fallon, Kenneth B., Farlow, Martin R. , Frosch, Matthew P. , Gearing, Marla , Geschwind, Daniel H. , Gilbert, John R., Glass, Jonathan D. , Growdon, John H., Håkonarson, Håkon , Hamilton, Ronald L. , Hardy, John , Harrell, Lindy E., Huentelman, Matthew J. , Hulette, Christine M., Jarvik, Gail P. , Jicha, Gregory A. , Jin, Lee‐Way, Karydas, Anna, Koo, Edward H. , Kowall, Neil W. , Kramer, Joel H. , LaFerla, Frank M. , Leverenz, James B. , Ge, Li , Lieberman, Andrew P. , Lin, Chiao‐Feng , Lyketsos, Constantine G. , Mack, Wendy J. , Marson, Daniel , Martiniuk, Frank , Mash, Deborah C. , Masliah, Eliezer , McCormick, Wayne C., McKee, Ann C. , Mesulam, Marsel, Miller, Carol A., Miller, Joshua W., Morris, John C. , Murrell, Jill R. , Olichney, John , Parisi, Joseph E., Partch, Amanda, Paulson, Henry L. , Peskind, Elaine R. , Petersen, Ronald , Pierce, Aimee, Poon, Wayne W. , Raj, Ashok , Raskind, Murray A. , Reisch, Joan, Ringman, John M. , Rosen, Howard J., Rosenberg, Roger N., Royall, Donald R., Sager, Mark A., Sano, Mary , Saykin, Andrew J. , Schneider, Lon S. , Smith, Amanda , Sonnen, Joshua A. , Tanzi, Rudolph E. , Thornton‐Wells, Tricia A., Trojanowski, John Q. , Troncoso, Juan C. , Vinters, Harry V. , Vonsattel, Jean Paul, Weıntraub, Sandra , Wishnek, Sarah, Woltjer, Randall L. , Wright, Clinton B., Wu, Chuang‐Kuo, Yu, Chang‐En , Yu, Lei , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard, Lunetta, Kathryn L. , Farrer, Lindsay A. , Bennett, David A. , Mez, Jesse , Barber, Robert C. , Carrasquillo, Minerva M. , Cruchaga, Carlos , Foroud, Tatiana , Hamilton‐Nelson, Kara L. , Inzelberg, Rivka , Kamboh, M. Ilyas , Kauwe, John S. K. , Logue, Mark W. , Manly, Jennifer J. , Mukherjee, Shubhabrata , Naj, Adam Christian , Sherva, Richard , Vardarajan, Badri Narayan , Barnes, Lisa L. , Becker, James T. , Boeve, Bradley F. , Burke, James R. , Carlsson, Cynthia M. , Chui, Helena C. , Crocco, Elizabeth , DeCarli, Charles , Dickson, Dennis W. , Duara, Ranjan , Ferris, Steven H. , Galasko, Douglas , Ghetti, Bernardino , Green, Robert C. , Head, Elizabeth , Honig, Lawrence S. , Huebinger, Ryan , Hyman, Bradley T. , Kaye, Jeffrey , Kim, Ronald , Lah, James J. , Levey, Allan I. , Li, Ge, López, Oscar L. , McCurry, Susan M. , McDavid, Andrew , Mesulam, Marsel M. , Miller, Bruce L. , Myers, Amanda , O’Bryant, Sid E. , Pankratz, V. Shane , Perry, William , Potter, Huntington , Quinn, Joseph F. , Reisberg, Barry , Roberson, Erik D. , Rogaeva, Ekaterina A. , Schneider, Julie A. , Seeley, William W. , Spina, Salvatore , Stern, Robert A. , Tsuang, Debby W. , Deerlin, Vivianna M. Van , Eldik, Linda J. Van , Welsh-Bohmer, Kathleen Anne , Williamson, Jennifer , Zhang, Xiaoling , Hakonarson, Hakon , Saykin, Andrew J , Leverenz, James B , Jarvik, Gail P , Paulson, Henry L , Hardy, John , Morris, John C , Goate, Alison M , Jicha, Gregory A , Sonnen, Joshua
Alzheimer's & Dementia | February 6, 2017 | Volume: 13 | Issue: 7 | Pages: 727-738
Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests ( P < 5 × 10 −8 ) were identified for SNPs in PFDN1/HBEGF , USP6NL/ECHDC3 , and BZRAP1‐AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence ( P < 2.7 × 10 −6 ) for gene‐based association in the total sample with a novel locus, TPBG ( P = 1.8 × 10 −6 ). Discussion Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
P3‐309: Advancing research and treatment of frontotemporal lobar degeneration (ARTFL): Preparing for clinical trials for ftld in north america
Boxer, Adam L. , Rosen, Howard J. , Bordelon, Yvette , Coppola, Giovanni , Dickerson, Brad C., Ghoshal, Nupur , Graff-Radford, N. R., Huey, Edward D. , Kaufer, Daniel , Kornak, John , Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Rademakers, Rosa , Weıntraub, Sandra , Boeve, Bradley F. , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Litvan, Irene , Knopman, David S. , Miller, Bruce L. , Tartaglia, Maria Carmela
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_16 | Pages: No page available
Diffuse leukoencephalopathy with spheroids presenting as primary progressive aphasia
Oboudiyat, Carly, Bigio, Eileen H. , Bonakdarpour, Borna , Baker, Matt , Rademakers, Rosa , Weıntraub, Sandra , Mesulam, M.‐Marsel, Baker, Matt C
Neurology | July 22, 2015 | Volume: 85 | Issue: 7 | Pages: 652-653