Citations 1
Characterization of "Peak E," a Novel Amino Acid Associated with Eosinophilia-Myalgia Syndrome
Mayeno, Arthur N., Foote, Christopher S., Loegering, David A., Ames, Matthew M. , Hedberg, Craig W. , Gleich, Gerald J. , Lin, Feng
Science | October 5, 2006 | Volume: 250 | Issue: 4988 | Pages: 1707-1708
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan Nα-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1′-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.