Citations

Showing 10 of 108048 citations.

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities
Pistollato, Francesca , Ohayon, Elan, Lam, Ann , Langley, Gillian R. , Novak, Thomas J., Pamies, David , Perry, George , Trushina, Eugenia , Williams, Robin S. B. , Roher, Alex E., Härtung, Thomas , Morris, Martha Clare, Lai, Mei-Chun, Merkley, Ryan, Chandrasekera, P. Charukeshi, Harnad, Stevan R. , Barnard, Neal D. , Trushina, Eugenia

Mayo Clinic

Oncotarget | May 6, 2016 | Volume: 7 | Issue: 26 | Pages: 38999-39016

10.18632/oncotarget.9175 | PMID 27229915 Get It

Complications and Outcomes of One-Bone Forearm Reconstruction
Kim, So Yeon , Chim, Harvey , Bishop, Allen T. , Shin, Alexander Y.

Mayo Clinic

HAND | May 6, 2016 | Volume: 12 | Issue: 2 | Pages: 140-144

10.1177/1558944716643305 | PMID 28344524 Get It

Background: The objective of this study was to review the outcomes of patients who underwent one-bone forearm (OBF) reconstruction. Methods: A retrospective review of patients who underwent OBF surgery between 1994 and 2014 was undertaken. Patient demographics, etiology, associated injuries, number of surgeries prior to OBF surgery, surgical details, and postoperative information were collected. A telephone interview was conducted at final follow-up, including a Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire, a 10-point scoring system used by Peterson et al, and a series of questions concerning pain and patient satisfaction. Results: There were 6 males and 2 females with a mean age of 44 years (range, 20-66 years). All patients had traumatic etiology, with 6 having open wounds and 2 having closed wounds. All patients had union with a mean follow-up of 83.6 months (range, 16-218 months). The mean pain score was 3 (range, 0-8), of which 3 were painless (score 0). The mean QuickDASH score was 39 (range, 7-75), and 4 patients had good or excellent results according to the 10-point score system used by Peterson et al. All patients were satisfied with the result. Five of 8 had complications related to soft tissues that were residual from their prior injuries and surgeries. One patient had post healing fracture requiring revision fixation and 1 had a postoperative infection requiring parenteral antibiotics. Conclusions: OBF surgery is an effective salvage procedure for complicated forearm instability, particularly after trauma. While union rates are high, complications are typically related to pain and soft tissue secondary to the previous injury and reconstructive procedures.
Long-Term Outcomes of Scaphoid Malunion
Gillette, Blake P., Amadio, Peter C. , Kakar, Sanjeev

Mayo Clinic

HAND | May 6, 2016 | Volume: 12 | Issue: 1 | Pages: 26-30

10.1177/1558944716643295 | PMID 28082839 Get It

Background: The optimal treatment of patients with a scaphoid malunion remains controversial. The long-term outcomes of operative and nonoperative management have not been established. Methods: We conducted a retrospective review of the outcomes of all scaphoid malunions treated at single institution over a 30-year period. This included patients who underwent corrective osteotomy, salvage procedures (ie, dorsal cheilectomy, radial styloidectomy, and scaphoidectomy with midcarpal fusion), and those who refused operative intervention. The Mayo Wrist Score was determined at the time of surgical evaluation. Patient-Rated Wrist Evaluation (PRWE) and Disabilities of the Arm, Shoulder and Hand (QuickDASH) surveys were sent to all patients for long-term follow-up. Results: Seventeen patients had follow-up at a mean 21.4 years (range, 12-30 years). The mean initial lateral intrascaphoid angle was 58°. Of the 17 patients, 11 proceeded with surgery and 6 opted for nonoperative management. A corrective osteotomy was performed in 4 patients. Of the remaining 7 surgical patients, 5 patients underwent procedures such as cheilectomy and radial styloidectomy, whereas 2 patients had a scaphoidectomy with midcarpal fusion. The final mean PRWE and QuickDASH scores for corrective osteotomy, salvage procedures, and nonoperative treatment were 23 and 6, 18 and 10, and 33 and 22, respectively. Conclusion: Long-term outcomes were similar between operative and nonoperative management.
Capitate Chondroblastoma
Izadpanah, Ali, Zreik, Riyam , Shives, Thomas C., Zreik, Riyam T, Shives, Thomas, Kakar, Sanjeev

Mayo Clinic

HAND | May 6, 2016 | Volume: 12 | Issue: 2 | Pages: NP14-NP18

10.1177/1558944716642762 | PMID 28344536 Get It

Background: Chondroblastomas are benign tumors that typically occur in the epiphysis of long bones. Carpal bone chondroblastomas are very rare and are known to have less aggressive behavior with no evidence of recurrence reported. Methods: We present a case of a recurrent chondroblastoma in the capitate that was treated with repeat curettage, application of phenol, and bone grafting. Results: At 3 years post surgery, the patient is disease free with excellent functional return. Conclusion: Chondroblastomas are rare within the carpus. We present a review of the literature detailing their occurrence and treatment.
Proximal Scaphoid Pole Reconstruction Utilizing Ipsilateral Proximal Hamate Autograft
Elhassan, Bassem T. , Noureldin, Mohamed , Elhassan, Bassem, Elhassan, Bassem T. , Kakar, Sanjeev

Mayo Clinic

HAND | May 6, 2016 | Volume: 11 | Issue: 4 | Pages: 495-499

10.1177/1558944716628497 | PMID 28149221 Get It

Background: Fractures of the proximal pole of the scaphoid can be difficult to heal because of its limited vascular supply. Furthermore, nonunion with avascular necrosis and secondary fragmentation makes surgical reconstruction a challenging procedure. Method: We describe a technique and report the outcome of a proximal hamate autograft to treat a proximal pole scaphoid nonunion with avascular necrosis. Results: At 3.5 years post reconstruction, the patient remains asymptomatic with union of his scaphoid reconstruction without any evidence of scapholunate instability. Conclusion: Proximal hamate autograft is a useful technique for addressing proximal pole scaphoid nonunions with avascular necrosis.
Long-Term Outcomes of Primary Repair of Chronic Thumb Ulnar Collateral Ligament Injuries
Sarfani, Shumaila , Shin, Alexander Y. , Christensen, Thomas, Christensen, Thomas , Kakar, Sanjeev , Shin, Alexander Y

Mayo Clinic

HAND | May 6, 2016 | Volume: 11 | Issue: 3 | Pages: 303-309

10.1177/1558944716628482 | PMID 27698632 Get It

Background: The purpose of this study is to evaluate long-term outcomes of ligamentous repair rather than reconstruction for chronic thumb ulnar collateral ligament (UCL) injuries. Methods: Patients at least 15-years status-post repair of a chronic (greater than 6 weeks) UCL tear were contacted for clinical evaluation, radiographs, and postoperative outcome questionnaires, including the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, visual analog scale (VAS) pain scale, and study-specific questions. Twelve of 21 (57%) living patients were available for long-term, greater than 15-year follow-up (average 24.5 years, range 16.9-35.6). Results: Eighty-eight percent of patients had some degree of osteoarthritis. Increased age at the time of injury and higher DASH scores were correlated with increased grades of the thumb metacarpophalangeal osteoarthritis. Delay to treatment and VAS pain scores had no correlation with radiographic findings. Conclusions: Repair of a chronic UCL injury with available local tissue appears to be a reasonable alternative to ligament reconstruction, resulting in durable long-term outcomes despite the majority of patients progressing to osteoarthritis.
Bilateral Legg-Calve-Perthes Disease and Kienbock’s Disease in a Child With Factor V Leiden Thrombophilia
Baltzer, Heather L. , Riester, Scott M. , Moran, Steven L. , Riester, Scott

Mayo Clinic

HAND | May 6, 2016 | Volume: 11 | Issue: 3 | Pages: NP16-NP19

10.1177/1558944715627274 | PMID 27698645 Get It

Background: The etiology of multifocal osteonecrosis is not definitively known; however, hypercoagulable state is a very plausible cause. Methods: We present an unusual case of a 12-year-old boy with a history of Legg-Calve-Perthes disease presenting with right wrist pain who was subsequently diagnosed with Kienbock’s disease. The finding of multifocal osteonecrosis prompted testing for a hypercoagulable state that was positive for Factor V Leiden thrombophilia. A thorough literature review using Medline database was conducted to investigate associations between inherited hypercoagulable states and multifocal osteonecrosis. Results: Our literature review identified 2 similar cases of multifocal osteonecrosis associated with a hypercoagulable disorder in adult patients. There were no reports among the pediatric patient population. Meta-analysis has demonstrated a potential link between Legg-Calve-Perthes disease and Factor V Leiden thrombophilia. Conclusions: This study offers further evidence to support the theory that multifocal osteonecrosis may be linked to a hypercoagulable state. Patients presenting with multifocal osteonecrosis should undergo screening for hypercoagulable states. Further investigation is needed to ascertain the potential benefit of prophylactic anticoagulation in patients with a known hypercoagulable state and multifocal osteonecrosis.
Predicting Fracture Risk for Enchondroma of the Hand
Riester, Scott M. , Ramaesch, Rishi, Wenger, Doris E. , Wijnen, André J. van , Riester, Scott, Wenger, Doris, van Wijnen, Andre, Kakar, Sanjeev , van Wijnen, Andre J

Mayo Clinic

HAND | May 6, 2016 | Volume: 11 | Issue: 2 | Pages: 206-210

10.1177/1558944715626931 | PMID 27390564 Get It

Background: Enchondromas are benign cartilage tumors that can cause pathologic fractures involving the digits of the hand. The purpose of this study is to identify objective reproducible clinical criteria that are associated with fracture that can be used to guide clinical decision making. Methods: A total of 54 enchondroma cases involving the hand were retrospectively reviewed. Criteria examined included age, gender, the hand involved (left vs right), bone involved, the digit involved, and longitudinal percentage of the bone occupied by the lesion on anteroposterior (AP) radiographs. Results: There was a statistically significant difference between the fracture and nonfracture group in regard to age, the digit involved, bone involved, and the percentage of bone occupied by the lesion on AP radiographs. Conclusion: This investigation provides evidence that patient age, the affected finger, the affected bone, and the percentage of the bone occupied by the pathologic lesion on AP radiographs can be used to predict pathologic fracture risk for enchondromas.
Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC‐NCS)
Li, Danni , Misialek, Jeffrey R. , Boerwinkle, Eric , Sharrett, A. Richey, Wruck, Lisa , Gottesman, Rebecca F. , Mosley, Thomas H. , Coresh, Josef , Knopman, David S. , Alonso, Álvaro , Wruck, Lisa M

Mayo Clinic

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | May 6, 2016 | Volume: 3 | Issue: 1 | Pages: 73-82

10.1016/j.dadm.2016.02.008 | PMID 27408938 Get It

AbstractIntroductionPhospholipids are altered in brains of patients with dementia and some studies suggest their plasma levels may be useful in the detection of mild cognitive impairment (MCI) and dementia.MethodsWe measured 188 plasma metabolites in participants who underwent a detailed neuropsychological assessment and classified as normal (n = 153), MCI (n = 145), or dementia (n = 143) by expert adjudication.ResultsAmong 10 phospholipids recently implicated as altered in dementia, higher concentration of PC aa C36:6 was significantly associated with decreased prevalence of dementia (odds ratio = 0.71, 95% confidence interval = 0.50–1.00 per 1−SD increase). Adding these phospholipids to a model including multiple predictors of dementia led to only minimal improvement in detection (C statistic changed from 0.702 to 0.71).DiscussionSome phospholipids and metabolites were altered in MCI and dementia but cross‐sectional association was relatively weak and did not improve detection of MCI and dementia beyond information provided by clinical variables.
A new pattern of lipomatosis of nerve: case report
Prasad, Nikhil , Howe, Benjamin M. , Amrami, Kimberly K. , Spinner, Robert J. , Mahan, Mark A

Mayo Clinic

Journal of Neurosurgery | May 6, 2016 | Volume: 126 | Issue: 3 | Pages: 933-937

10.3171/2016.2.jns151051 | PMID 27153174 Get It

Lipomatosis of nerve (LN) is a rare disorder of peripheral nerves that produces proliferation of interfascicular adipose tissue. It may be associated with soft-tissue and bony overgrowth within the affected nerve territory. LN has been almost exclusively reported in appendicular peripheral nerves; the median nerve at the wrist and palm is among the most common locations. The authors present a new pattern of LN that shows circumferential proliferation of fat around the epineurium of the nerve. They believe that this case and the two other documented examples in the literature (also affecting cervical and thoracic spinal nerves) share the same new pattern of LN. Defining the full spectrum of adipose lesions of the nerve and establishing a cause-effect relationship with nerve-territory overgrowth disorders may offer options for future management through targeted nerve lesioning.