Citations

Objective: The treatment of segmental bone defects remains challenging as complications frequently occur with the currently available methods, including vascularized autograft, prosthetic replacement, bone transport, and cryopreserved bone allograft (CBA). Although the use of CBA is comparatively simple, it lacks donor site morbidity and provides immediate stability; however, the grafts remain largely necrotic, resulting in high failure rates due to nonunion, infection, and stress fractures. Revitalizing the CBA has the potential to solve these problems. Previous studies in small animal models have shown the use of surgical revascularization to induce neoangiogenesis and improve bone viability in the CBA. The purpose of this study is to investigate if surgical revascularization enhances bone circulation and bone remodeling in a tibial defect orthotopic reconstruction model, placing a cryopreserved allograft in a Yucatan mini pig. Methods: Cryopreserved tibial bone allografts were transplanted in swine leukocyte antigen (SLA)-type-mismatched Yucatan mini pigs after creating a 3.5-cm segmental bone defect in the tibia. The anterior tibial arteriovenous bundle (AV-bundle) was inserted into the intramedullary canal. Eight pigs received a patent AV-bundle (revascularized group), 8 pigs received a proximally ligated AV-bundle (control group), and the contralateral side was used as an untreated control. The graft was fixated with a locking compression plate to provide a weightbearing construction. After 20 weeks, the pigs were killed and the tibia was removed and analyzed. Neoangiogenesis was evaluated by quantifying vascular volumes using the microcomputed tomography. Bone remodeling was measured by quantitative histomorphometry and micro-computed tomography. Results: Seven AV-bundles in the revascularized group were patent and 1 bundle was thrombosed due to partial dislocation of the graft. Total vascular volume was higher in the revascularized allografts (127 mm 3 ) compared with both the control group (40 mm 3 , P = .003) and the contralateral side (29 mm 3 P = .000). All patent bundles showed neovascularization extending into the cortical bone. Revascularized allografts had increased bone remodeling in the inner cortical area of the graft compared with the non-revascularized grafts (bone formation rate: 381 ± 60 µm 3 /µm 3 /year vs 299 ± 143 µm 3 /µm 3 /year, P = .05). In both the revascularized group and the control group, the bone formation rate exceed the contralateral side: In the revascularized grafts, the bone formation was 305% of contralateral side, and in the non-revascularized grafts, the bone formation was 179% of the contralateral side. There was no statistical significant difference in outer cortical bone formation between the revascularized and the non-revascularized allografts. Conclusion: Surgical revascularization of porcine tibial CBAs by implantation of an AV-bundle creates an enhanced autogenous neoangiogenic circulation and accelerates active bone formation.

Objectives: We sought to determine the incidence of hardware removal or persistent irritation after tension band arthrodesis of the thumb metacarpophalangeal joint (MCPJ), and whether these outcomes were related to patient age, gender, body mass index (BMI), or angle of fusion. Materials and Methods: A retrospective review was performed of all (n = 39) thumb MCPJ arthrodesis done using tension band wire fixation by a single hand surgeon at a large tertiary academic medical center over a 14-year period. Thirty procedures in 28 patients (4 men, 24 women) with an average age of 65 years (range, 35-81 years) were available for long-term follow-up (mean, 82 months; range, 12-171 months). Average BMI was 26.2 (range, 17.4-35).Most were done in conjunction with a basal joint suspensionplasty. Results: One hundred percent of arthrodesis healed radiographically at a mean 3.8 months (range, 3-7 months). Mean fusion angle was 24° (range, 9°-45°). Of patients available for long-term follow-up (n = 30), 7 (23%) required hardware removal for pain at a mean of 36 months postoperatively, and another needed revision of hardware at 4 months postoperatively. An additional 3 patients (10%) expressed dissatisfaction with the hardware in place, but declined removal. There was no significant influence of the above variables on hardware removal or dissatisfaction. Conclusions: Tension band wire arthrodesis of the thumb MCPJ results in predictable bony union. Although it is a very cheap means of fixation, there is a 33% incidence of significant hardware-related pain after tension band arthrodesis of the thumb MCPJ. Twenty-five percent of patients may require a second surgery to revise or remove symptomatic hardware, which can negate any cost savings through the use of this technique. A study comparing this method with plate or single screw fixation would be beneficial.

Background: Proximal interphalangeal joint (PIPJ) arthroplasty in border digits is controversial because of unprotected external loading forces and limited canal sizes in the small finger. The use of neither a semiconstrained, surface replacement proximal arthroplasty (SRA) nor a lateral approach that preserves the external collateral ligament has been well described. Methods: Eight women (mean age, 66 years) underwent SRA of 5 index and 4 small digits for osteoarthritis. Active range of motion, deformity, and grip and pinch strengths were measured, and patients completed a visual analog pain scale, QuickDASH, and satisfaction survey. Radiographs were assessed for implant loosening or subsidence. Results: Mean follow-up was 29 months. Mean pain score decreased from 8.0 to 0.8. Mean coronal deformity decreased from 22° ulnar deviation to 6°. Average PIPJ arc of motion improved from 51° to 56°. No lateral instability was observed. Final lateral pinch averaged 4.4 kg in affected vs 4.0 kg in opposite hand. Average final grip strength was 19 kg in affected vs 16 kg in opposite hand. Postoperative QuickDASH averaged 24; postoperative satisfaction score averaged 3.7 (5-point Likert scale). Radiographic analysis showed no implant subsidence or radiolucent lines. Conclusions: PIPJ SRA appears to be a reasonable option in border digits, as is a lateral approach on the inside border of the affected digit. Pain relief and lateral stability are predictable, and motion improves slightly. If a longitudinal incision is made, placement slightly dorsal to the midaxial line away from the digital nerve may help to avoid a tender scar.

AbstractThrombotic thrombocytopenic purpura (TTP) has >90% mortality without therapeutic plasma exchange (TPE). Despite TPE, approximately 10% of patients still die, presumably from cardiac ischemia. We sought clinical or laboratory parameters associated with death by reviewing the records of all patients hospitalized with acquired TTP in our institution for 10 years, and collect demographics and results for hemoglobin, platelet count, creatinine, lactate dehydrogenase, transaminases, total bilirubin, creatinine kinase (CK), CK‐MB, and troponin I. Sixty‐eight patients were admitted 88 times, and 11 died. Survivors and non‐survivors were similar in terms of sex, ethnicity, thrombocytopenia, and degree of anemia at presentation, while the latter were older, had worse renal function and higher CK, CK‐MB, and troponin I (univariate analysis). However, only troponin I remained significant on multivariate analyses. We propose that patients with TTP should be monitored with troponin I to detect significant myocardial ischemia that could predict death despite TPE.

Pembrolizumab, a programmed cell death protein 1 (PD‐1) inhibitor, is a humanized monoclonal antibody used in the treatment of metastatic or unresectable melanoma and advanced non–small cell lung cancer (NSCLC). We hereby report a case of pembrolizumab‐induced uveitis to increase practitioner awareness. A 78‐year‐old woman presented with onset of panuveitis after initiation of pembrolizumab therapy for metastatic melanoma. The patient received three cycles of therapy every 21 days, during which her symptoms progressively worsened. She was treated with topical and systemic corticosteroids, and further pembrolizumab was discontinued despite a good response to therapy. Pembrolizumab has been associated with rapid onset of ocular inflammation and uveitis. PD‐1 inhibitors mediate a T‐cell response against cancer cells; however, autoimmune complications have been reported. Incidence of pembrolizumab‐induced uveitis is reported to be < 1%. To date, three cases have been reported since its Food and Drug Administration approval in September 2014. Uveitis, if left untreated, may lead to permanent vision loss and ocular damage. Cases of immune‐mediated uveitis have been reported with cancer immunotherapies. Oncologists and ophthalmologists should be aware of this complication. With the increasing targeted pharmaceuticals in oncology, effective management of adverse events is necessary to ensure patient safety and optimal outcomes.

Objective/HypothesisEosinophilic otitis media (EOM) is a variant of chronic otitis media that is characterized by the development of thick mucoid middle ear effusion, adult onset bronchial asthma, sinonasal polyposis, and aspirin sensitivity. EOM is typically refractory to corticosteroid therapy and surgical intervention. Pegylated interferon (PEG‐IFN) has effectively treated hypereosinophilic syndrome in clinical trials; however, the efficacy of this medication for EOM treatment remains undefined.Study DesignRetrospective, case series, tertiary academic center.MethodsA retrospective chart review was performed on EOM patients from 2008–2014. A total of 32 patients met the clinical criteria for EOM according to established diagnostic guidelines. Outcomes of all patients with severe, refractory EOM who initiated PEG‐IFN therapy are reported.ResultsEight patients were treated with pegylated interferon‐α 2a or 2b for refractory EOM. Half of the patients had significant side effects with interferon treatment. Three of these were able to continue at a reduced dosage without side effect reoccurrence, and one patient stopped the medication permanently. Four of eight (50%) patients had a complete clinical response with total resolution of otorrhea and normalization of middle ear mucosa, and were able to discontinue corticosteroid treatment. Two patients attempted to stop PEG‐IFN therapy after prolonged symptom remission and had recurrent otorrhea. Both patients had symptom resolution after PEG‐IFN reinitiation.ConclusionsThese data demonstrate that pegylated interferon‐α 2a and 2b therapy may benefit patients with severe, refractory EOM. Further larger studies with long‐term follow‐up are required to validate these early but promising results.Level of Evidence4. Laryngoscope, 127:1208–1216, 2017