Citations

Showing 10 of 108073 citations.

The Capabilities and Limitations of Clinical Magnetic Resonance Imaging for Detecting Kidney Stones: A Retrospective Study
Ibrahim, El-Sayed H. , Cernigliaro, Joseph G. , Bridges, Mellena D., Pooley, Robert A. , Haley, William E. , Haley, William E

Mayo Clinic

International Journal of Biomedical Imaging | November 17, 2016 | Volume: 2016 | Issue: No issue available | Pages: 1-6

10.1155/2016/4935656 | PMID 27980535 Get It

The purpose of this work was to investigate the performance of currently available magnetic resonance imaging (MRI) for detecting kidney stones, compared to computed tomography (CT) results, and to determine the characteristics of successfully detected stones. Patients who had undergone both abdominal/pelvic CT and MRI exams within 30 days were studied. The images were reviewed by two expert radiologists blinded to the patients’ respective radiological diagnoses. The study consisted of four steps: (1) reviewing the MRI images and determining whether any kidney stone(s) are identified; (2) reviewing the corresponding CT images and confirming whether kidney stones are identified; (3) reviewing the MRI images a second time, armed with the information from the corresponding CT, noting whether any kidney stones are positively identified that were previously missed; (4) for all stones MRI-confirmed on previous steps, the radiologist experts being asked to answer whether in retrospect, with knowledge of size and location on corresponding CT, these stones would be affirmed as confidently identified on MRI or not. In this best-case scenario involving knowledge of stones and their locations on concurrent CT, radiologist experts detected 19% of kidney stones on MRI, with stone size being a major factor for stone identification.
Pulmonary Hypertension and Palliative Care: What, When, Where, and Why?
Fenstad, Eric R. , Wordingham, Sara E., Swetz, Keith M.

Mayo Clinic

Advances in Pulmonary Hypertension | November 17, 2016 | Volume: 15 | Issue: 1 | Pages: 26-31

10.21693/1933-088x.15.1.26 Get It

Summary: Pulmonary hypertension (PH) can be associated with a high level of symptom burden from the disease as well as its treatment. Involvement of palliative care (PC) services may help facilitate discussion regarding goals of care, prognostic planning, and treatment options focused on improving quality of life (QOL). Background: PC is active total care of a patient whose disease is not fully responsive to curative therapies, with symptom control as the top priority. After a life-limiting diagnosis is made, health care teams and patients determine prognosis, whether cure is attainable or reasonable, what treatment options are available, risks and benefits of associated treatments, and how treatment or nontreatment will impact QOL and survival. QOL is often the focus of palliative interventions, with the goal to minimize symptoms and empower patients with accurate information to help affirm life and meet objectives of care. Implications for clinicians: PC can begin at the onset of symptoms in a disease that cannot be cured. Early PC may help facilitate discussion regarding goals of care when patient expectations are discordant with prognosis. While PC is a responsibility of all clinicians, subspecialist assistance can be helpful when a clinical decline occurs, in the setting of uncertainty, when patients are removed from the transplant list, or when long-term QOL issues are present. Conclusion: Communication with patients who have PH can be delicate and requires an understanding of the disease's process, trajectory, and prognosis. PC teams possess communication skills that may benefit patients and providers with QOL optimization, delivery of difficult news, advanced care planning, and shared decision-making.
Editor's Memo
Burger, Charles D.

Mayo Clinic

Advances in Pulmonary Hypertension | November 17, 2016 | Volume: 15 | Issue: 1 | Pages: 2-2

10.21693/1933-088x.15.1.2.1 Get It

Editor's Memo
Burger, Charles D.

Mayo Clinic

Advances in Pulmonary Hypertension | November 17, 2016 | Volume: 15 | Issue: 2 | Pages: 58-58

10.21693/1933-088x-15.2.58a Get It

Faculty Opinions recommendation of MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.
Meng, Wei , Kaufmann, Scott H.

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.725518097.793525480 Get It

Faculty Opinions recommendation of Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
Kaufmann, Scott H.

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.725369660.793525483 Get It

Faculty Opinions recommendation of Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Meng, Wei , Kaufmann, Scott H.

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.725314829.793525479 Get It

Faculty Opinions recommendation of Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
Meng, Wei , Kaufmann, Scott H. , Dai, Haiming

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718479856.793525482 Get It

Faculty Opinions recommendation of Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.
Meng, Wei , Kaufmann, Scott H.

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718232311.793525481 Get It

Faculty Opinions recommendation of Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.
Meng, Wei , Kaufmann, Scott H.

Mayo Clinic

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 17, 2016 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.726638619.793525472 Get It