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152 citation(s) found for "An, Kai‐Nan".

AUTOMATED RANGE-OF-MOTION DEVICE FOR TOTAL HIP ARTHROPLASTY PROSTHESIS
Prabhakar, Prashanth P., Chen, Qingshan , Schultz, Fredrick M., Lazennec, Jean Yves , An, Kai‐Nan

Mayo Clinic

Journal of Musculoskeletal Research | April 5, 2007 | Volume: 10 | Issue: 03 | Pages: 151-155

10.1142/s0218957706001790 Get It

Hip simulators are regularly used by researchers to assess total hip arthroplasty (THA) implants, range of motion, stability, and alignment of acetabular cup and stem. Previous papers have described three types of simulators: three-dimensional protractors, biaxial rocking motion (BRM) protractors, and single-axis prosthetic range-of-motion (PROM) devices. We have developed a new hip simulator in which the ROM device is completely automated in three independent axes (elevation, internal/external rotation, and plane of elevation). Coupled with the simulator, we used a FaroArm Gold Series coordinate measuring machine (CMM) to accurately align the implant components. The results show that the methodology and alignment setup are accurate and repeatable. With this simulator and digitizer, we are able to study the characteristics of numerous THA implants at various orientations of the pelvis, acetabular cup, stem, and femur.
Theoretical Analysis of Fracture Healing Monitoring with External Fixators
An, Kai‐Nan, Kasman, Roberta A., Chao, Edmund Y.S.

Mayo Clinic

Engineering in Medicine | February 20, 2007 | Volume: 17 | Issue: 1 | Pages: 11-15

10.1243/emed_jour_1988_017_006_02 | PMID 3366291 Get It

A fracture healing monitoring system with external fixators was analysed using the finite element method. Pin displacement and side bar strain under axial and side loading were evaluated at various stages of simulated fracture healing. In general, a recovery of rigidity at the fracture site of up of 25 percent of intact bone could be sensitively predicted. Effects of cross-sectional distribution and length of callus at the fracture site on pin displacement and side bar strain were studied. Alterations of fixation configuration, such as component failure during the healing process, were found to have relatively little effect on pin displacement but a rather larger effect on side bar strain. In general, the assessment of fracture healing by monitoring the deformation of external fixation devices is a useful idea. However, in practice, great care must be taken to fully understand the implication of the monitoring system before drawing conclusions on such measurements.
IN VIVO LOCATION OF JOINT CENTERS OF THE SHOULDER SYSTEM: GLENO-HUMERAL AND SCAPULO-THORACIC JOINTS BETWEEN TWO POSTURES DESCRIBING THE ARM ELEVATION IN THE PLANE OF SCAPULA USING TECHNIQUES BASED UPON BIPLANAR RADIOGRAPHY
Berthonnaud, Éric , Herzberg, Guillaume , Morrow, Duane A., An, Kai‐Nan, Dimnet, J.

Mayo Clinic

Journal of Mechanics in Medicine and Biology | January 8, 2007 | Volume: 06 | Issue: 04 | Pages: 385-397

10.1142/s0219519406002060 Get It

In biomechanics, the knowledge of accurate location of a joint center is essential because equilibration of the external loads and muscular forces about the joint is performed about this specific point. This paper focuses on the location of centers of gleno-humeral joint and scapulo-thoracic joint in a subject moving their arm in the scapular plane with a magnitude of 120°. Biplanar radiography with successive exposures has been used locating anatomical axes of bones. Geometric models of bones were defined allowing access to bone morphology by superposing model projections onto X-ray imaged bone contours. Functional models were used so as to represent the behavior in motion of shoulder joints. These techniques allowed us to access to results describing the linear and angular relative displacements of the shoulder bones between two different postures. The gleno-humeral and scapulo-thoracic finite joint centers (F H and F S ) are first defined through the location of the corresponding helical axis of motion (HAM) moving the joint from positions occupied in initial and final postures. The gleno-humeral and scapulo-thoracic mean joint centers (M H and M S ) are then calculated using a new technique, which defines that each joint center has the point having the smallest migrations while moving continuously from initial to final postures. This allows for the analysis of the linear and angular clearances, which affect joint center migration. The whole continuous movement has been parsed into several steps to test the stability of the mean joint center throughout the motion.
Comparative Anatomy of the Subsynovial Connective Tissue in the Carpal Tunnel of the Rat, Rabbit, Dog, Baboon, and Human
Ettema, Anke M., Zhao, Chunfeng , An, Kai‐Nan, Amadio, Peter C.

Mayo Clinic

HAND | November 9, 2006 | Volume: 1 | Issue: 2 | Pages: 78-84

10.1007/s11552-006-9009-z | PMID 18780029 Get It

The tenosynovium in the human carpal tunnel is connected to the flexor tendons and the median nerve by the subsynovial connective tissue (SSCT). The most common histological finding in carpal tunnel syndrome (CTS), a compression neuropathy of the median nerve, is noninflammatory fibrosis of the SSCT. The relationship, if any, between the fibrosis and nerve pathology is unknown, although some have speculated that a change in the SSCT volume or stiffness might be the source of the compression. Yet, while animal models have been used to study the physiology of nerve compression, so far none have been used to study the relationship of the SSCT pathology to the neurophysiological abnormalities. The purpose of this study was to identify animal models that might be appropriate to study the interaction of SSCT and nerve function in the development of CTS. The front paws of a rat, rabbit, dog, and baboon were dissected. The carpal tunnel anatomy and SSCT of these animals were also examined by light and scanning microscopy and compared to the relevant human anatomy and ultrastructure. The carpal tunnel anatomy and contents of the baboon and rabbit are similar to humans. The canine carpal tunnel lacks the superficial flexor tendons and the rat carpal tunnel is very small. The human, baboon, and rabbit specimens had very similar organization of the SSCT, and content of the carpal canal. We conclude that, while both the baboon and rabbit would be good animal models to study the relationship of the SSCT to CTS, the rabbit is likely to be more practical, in terms of cost and animal care concerns.
Rotator Cuff Repair Using an Acellular Dermal Matrix Graft: An In Vivo Study in a Canine Model
Adams, Julie E. , Zobitz, Mark E., Reach, John S., An, Kai‐Nan , Steinmann, Scott P. , Adams, Julie , Adams, Julie E

Mayo Clinic

Arthroscopy | August 21, 2006 | Volume: 22 | Issue: 7 | Pages: 700-709

10.1016/j.arthro.2006.03.016 | PMID 16843804 Get It

Purpose Large rotator cuff tears present a challenge to orthopaedic surgeons. Because tissue may be insufficient or of inadequate quality to undergo repair, a variety of materials have been used as adjuncts. Human dermal tissue may be processed to render it acellular, and thus less immunogenic, but with the extracellular matrix left intact, creating a collagen scaffold with favorable characteristics. Because of these traits, use in rotator cuff repair was proposed. Methods A canine model for a full‐thickness infraspinatus tendon tear was used. Tendon was excised from the bony interface to the myotendinous junction, and a human acellular dermal matrix graft (experimental) or the autologous excised tendon (control) was used to bridge the defect. Animals were sacrificed, and shoulders were evaluated histologically and biomechanically. Results At time 0, strength of control and experimental repairs was similar. At 6 weeks, the strength of the experimental repair was half that of the control side. Strength of control specimens remained the same at 6 and 12 weeks, but by 12 weeks, the strength of the experimental repair was equal to that of the control. Histologically, cells infiltrated the control and experimental specimens by 6 weeks; chronic inflammation was consistent with surgery and repair. At 6 months, control and experimental specimens mimicked normal tendon structure grossly and histologically. Conclusions Use of human acellular dermal matrix as a patch is a viable option in this model of large rotator cuff defects. Within 6 weeks, histologic evidence of native cell infiltration and neotendon development was observed. Within 12 weeks, the strength of the dermal matrix graft repair was equivalent to that of autologous tendon. At 6 months, control and graft specimens mimicked normal tendon structure grossly and histologically. Clinical Relevance This study provides in vivo animal data to support the use of this acellular dermal matrix graft for repair of full‐thickness rotator cuff defects. Additional studies are indicated to determine the role of this material in the treatment of humans with rotator cuff tears.
Intraarticular pressure of the shoulder
Motzkin, Neil E., Browne, A.O., Hoffmeyer, Pierre , Morrey, B.F. , An, Kai‐Nan , Itoi, Eiji

Mayo Clinic

Arthroscopy | July 22, 2006 | Volume: 9 | Issue: 4 | Pages: 406-413

10.1016/s0749-8063(05)80314-7 | PMID 8216571 Get It

Summary Nine fresh frozen cadaveric shoulders were used to examine the changes in intraarticular pressure (IAP) of the shoulder joint and the position of the humeral head under various loads to determine the relationship between these parameters. All the soft tissues superficial to the rotator cuff were removed. The position of the humerus relative to the scapula was monitored using an electromagnetic tracking system before and after venting the capsule with 0, 0.5, and 1.0 kg of load applied to the humerus inferiorly in addition to the weight of the arm. Simultaneously, the IAP was monitored using a pressure transducer before venting the capsule. Venting had a significant effect on the position of the humeral head: the positions of the head after venting were significantly lowered in all loading conditions. The average IAP was −76 cm H 2 O without load, and the value decreased in a linear fashion with increased load; the correlations were significant in four of six shoulders without dislocation. The correlations were less significant between the pressure and the position, and there were no significant correlations between the load and the position. IAP, which is determined primarily by the load applied, is important to stabilize the shoulder inferiorly. Because IAP is intimately related to the external load and the response is specific to individuals, examination of IAP response to external load may be helpful in characterizing various instabilities of the shoulder.
Healing of Canine Tendon in Zones Subjected to Different Mechanical Forces
Nessler, Joseph P., Amadio, Peter C. , Berglund, L. J., An, Kai‐Nan

Mayo Clinic

Journal of Hand Surgery | July 6, 2006 | Volume: 17 | Issue: 5 | Pages: 561-568

10.1016/s0266-7681(05)80242-6 | PMID 1479251 Get It

The effect of external force environment on the healing of a partial thickness injury to canine flexor tendon was studied. A 50% laceration was made in either the fibrocartilaginous (compressive) zone or in the tendinous (tensile) zone of canine flexor digitorum profundus tendons. After three or six weeks, the tendons were harvested. An optical method for determining zone-specific material properties showed that, in response to injury, the structural stiffness decreased in the tensile zone of the tendon but increased in the compressive zone. The mechanical properties and failure mechanism of canine tendon and their changes in response to injury vary according to tendon zone, and differences in the healing process in mechanically specialised zones of the flexor tendon are discussed.
Biomechanical Efficiency of Wrist Guards as a Shock Isolator
Hwang, Il-Kyu, Kim, Kyu-Jung, Kaufman, Kenton R. , Cooney, William P., An, Kai‐Nan , Kaufman, Kenton R

Mayo Clinic

Journal of Biomechanical Engineering | March 7, 2006 | Volume: 128 | Issue: 2 | Pages: 229-234

10.1115/1.2165695 | PMID 16524335 Get It

Despite the use of wrist guards during skate- and snowboard activities, fractures still occur at the wrist or at further proximal locations of the forearm. The main objectives of this study were to conduct a human subject testing under simulated falling conditions for measurement of the impact force on the hand, to model wrist guards as a shock isolator, to construct a linear mass-spring-damper model for quantification of the impact force attenuation (Q-ratio) and energy absorption (S-ratio), and to determine whether wrist guards play a role of an efficient shock isolator. While the falling direction (forward and backward) significantly influenced the impact responses, use of wrist guards provided minimal improvements in the Q- and S-ratios. It was suggested based on the results under the submaximal loading conditions that protective functions of the common wrist guard design could be enhanced with substantial increase in the damping ratio so as to maximize the energy absorption. This would bring forth minor deterioration in the impact force attenuation but significant increase in the energy absorption by 19%, which would help better protection against fall-related injuries of the upper extremity.
Development of a Biologic Prosthetic Composite for Cartilage Repair
Mardones, Rodrigo , Reinholz, Gregory G., Fitzsimmons, James S. , Zobitz, Mark E., An, Kai‐Nan , Lewallen, David G. , Yaszemski, Michael J. , O’Driscoll, Shawn W. , Fitzsimmons, James S

Mayo Clinic

Tissue Engineering | October 31, 2005 | Volume: 11 | Issue: 9-10 | Pages: 1368-1378

10.1089/ten.2005.11.1368 | PMID 16259592 Get It

The Capitohamate Ligaments
Ritt, Marco J.P.F. , Berger, Richard A. , An, Kai‐Nan , Bishop, Allen T.

Mayo Clinic

Journal of Hand Surgery | September 21, 2005 | Volume: 21 | Issue: 4 | Pages: 451-454

10.1016/s0266-7681(96)80044-1 | PMID 8856532 Get It

The physical attributes of the three capitohamate interosseous ligaments were tested in a computer-controlled multi-axis testing machine using 12 human cadaver specimens. After an intact test run, selected ligaments were cut in random sequence and the test repeated. The remaining ligaments were tested to failure with servohydrolic stress at 5 mm/second. In the intact joint complex, the average dorsopalmar rotational displacement was approximately 9° in each direction. Under the load limit, the dorsopalmar translational displacement averaged 0.9 mm and 0.5 mm respectively, proximal–distal translational displacement averaged 0.8 mm and 0.4 mm respectively, and distractional displacement averaged 0.3 mm. Based on the sequential sectioning it was found that the dorsal ligament provided 76% (SD 14) of the rotational resistance with palmar rotation of the capitate and 44% (SD 19) of translational constraint with palmar translation of the capitate. The deep ligament provided 51% (SD 15) of the rotational resistance with dorsal rotation of the capitate and 63% (SD 24) of translational resistance with dorsal translation of the capitate. With proximal—distal translation, the dorsal ligament was the most important constraint in each direction. In resisting distraction, each of the three ligaments was equally effective. Failure testing showed the deep ligament was strongest at 289 N, followed by the palmar at 171 N and the dorsal at 133 N.