Citations
151 citation(s) found for "Jagust, William".
APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
Risacher, Shannon L. , Kim, Sungeun , Shen, Li , Petersen, Ronald C. , Jack, Clifford R. , Aisen, Paul , Jagust, William J. , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Nho, Kwangsik T. , Foroud, Tatiana , Beckett, Laurel , Koeppe, Robert A. , Trojanowski, John Q., (ADNI), Alzheimer's Disease Neuroimaging Initiative, Jack, Clifford R , Saykin, Andrew J , Shen, Li
Alzheimer's & Dementia | May 7, 2015 | Volume: 11 | Issue: 12 | Pages: 1417-1429
10.1016/j.jalz.2015.03.003
| PMID 25960448
Abstract Introduction This study assessed apolipoprotein E ( APOE ) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). Methods Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ε4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses in SMC evaluated the effect of the interaction between APOE and [ 18 F]Florbetapir amyloid positivity on CSF biomarkers. Results SMC ε4+ showed greater amyloid deposition than SMC ε4−, but no hypometabolism or medial temporal lobe (MTL) atrophy. SMC ε4+ showed lower amyloid beta 1–42 and higher tau/p‐tau than ε4−, which was most abnormal in APOE ε4+ and cerebral amyloid positive SMC. Discussion SMC APOE ε4+ show abnormal changes in amyloid and tau biomarkers, but no hypometabolism or MTL neurodegeneration, reflecting the at‐risk nature of the SMC group and the importance of APOE in mediating this risk.
Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease
Toledo, Jon B. , Bjerke, Maria , Da, Xiao , Landau, Susan, Foster, Norman L. , Jagust, William, Jack, Clifford R. , Weiner, Michael W. , Davatzikos, Christos , Shaw, Leslie M. , Trojanowski, John Q. , Hsiung, Ging‐Yuek Robin , Preda, Adrian , Jicha, Gregory A. , Ponto, Laura L. Boles , Jack, Clifford R , Preda, Adrian , Hsiung, Gink-Yuek , Jicha, Gregory A
JAMA Neurology | March 30, 2015 | Volume: 72 | Issue: 5 | Pages: 571
Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures
Apostolova, Liana G. , Hwang, Kristy , Ávila, David, Elashoff, David , Kohannim, Omid , Teng, Edmond , Sokolow, Sophie , Jack, Clifford R. , Jagust, William, Shaw, Leslie M. , Trojanowski, John Q. , Weiner, Michael W. , Thompson, Paul M. , Initiative, For the Alzheimer's Disease Neuroimaging, Aisen, Paul, Petersen, Ronald , Jagust, Wiliam, Trojanowki, John Q., Gamst, Anthony, Sakin, Andrew J., Potter, William Z., Montine, Tom, Walter, Sarah , Felmlee, Joel P. , Schuff, Norbert, Alexander, Gene E. , DeCarli, Charles, Bandy, Dan, Foster, Norm, Reiman, Eric M. , Mathis, Chet, Cairns, Nigel J., Taylor‐Reinwald, Lisa, Shaw, Lee, Korecka, Magdalena , Crawford, Karen , Neu, Scott, Kornak, John , Kachaturian, Zaven, Frank, Richard , Molchan, Susan, Dolen, Sara, Schneider, Lon S. , Pawluczyk, Sonia, Spann, Bryan M., Brewer, James B., Vanderswag, Helen, Heidebrink, Judith L. , Johnson, Kris , Doody, Rachelle S., Villanueva‐Meyer, Javier , Chowdhury, Munir , Bell, Karen L. , Mintun, Mark A., Schneider, Stacy, Marson, Daniel , Griffith, Randall, Grossman, Hillel, Marzloff, George, deToledo‐Morrell, Leyla, Duara, Ranjan , Varón, Daniel , Robers, Peggy, Albert, Marilyn S. , Kozauer, Nicholas, Zerrate, Maria, Santi, Susan M De, Doraiswamy, P. Murali , Petrella, Jeffrey R. , Aiello, Marilyn, Karlawish, Jason , Smith, Charles D., Given, Curtis A., Hardy, Peter , Oakley, MaryAnn, Simpson, Donna M., Ismail, M. Saleem , Brand, Connie, Richard, Jennifer, Mulnard, Ruth A., Thai, Gaby , Mc-Adams-Ortiz, Catherine, Martin-Cook, Kristen, Devous, Michael D. , Cellar, Janet S., Anderson, Heather S., Laubinger, Mary M., Graff‐Radford, Neill R. , Parfitt, Francine, Farlow, Martin R. , Herring, Scott, Hake, Ann Marie , Dyck, Christopher H. van , MacAvoy, Martha G., Benincasa, Amanda L., Chertkow, Howard, Bergman, Howard , Hosein, Chris, Caldwell, Curtis, Hsiung, Ging‐Yuek Robin , Assaly, Michele, Kertesz, Andrew , Rogers, John, Trost, Dick, Bernick, Charles , Munic, Donna, Wu, Chuang‐Kuo, Johnson, Nancy , Mesulam, Marsel, Sadowsky, Carl, Villena, Teresa, Johnson, Kathleen, Reynolds, Brigid, Rosen, Allyson , Tinklenberg, Jared, Ashford, Wes, Sabbagh, Marwan N. , Connor, Donald J., Jacobson, Sandra A. , Jayam‐Trouth, Annapurni , Lerner, Alan J. , Hudson, Leon, Ogrocki, Paula, Kittur, Smita, Borrie, Michael, Lee, T‐Y, Asthana, Sanjay , Carlsson, Cynthia M., Preda, Adrian , Tariot, Pierre N. , Fleisher, Adam , Reeder, Stephanie, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Hendin, Barry , Kataki, Maria , Zimmerman, Earl A. , Celmins, Dzintra, Brown, Alice D., Blank, Karen, Anderson, Karen, Santulli, Robert B. , Englert, Jessica, Williamson, Jeff D. , Sing, Kaycee M., Watkins, Franklin, Ott, Brian R. , Stopa, Edward G., Tremont, Geoffrey , Salloway, Stephen , Malloy, Paul, Correia, Stephen , Rosen, Howard J. , Mintzer, Jacobo , Longmire, Crystal Flynn, Spicer, Kenneth, Hwang, Kristy S, Shaw, Leslie, Initiative, For the Alzheimer's Disease Neuroimaging, Toga, Arthur W. , Beckett, Laurel , Green, Robert C. , Morris, John C. , Donohue, Michael , Dale, Anders M. , Bernstein, Matt A. , Fox, Nick C. , Koeppe, Robert A. , Chen, Kewei , Mathis, Chet, Lee, Virginia M.‐Y. , Harvey, Danielle , Foroud, Tatiana , Potkin, Steven G. , Shen, Li , Snyder, Peter J. , Kaye, Jeffrey , Quinn, Joseph F. , Lord, Joanne L. , Stern, Yaakov , Honig, Lawrence S. , Clark, David , Tang, Cheuk Ying , Shah, Raj C. , Duara, Ranjan , Rusinek, Henry , Leon, Mony J. de , Arnold, S. R. , Wolk, David A. , López, Oscar L. , Diaz‐Arrastia, Ramon , Levey, Allan I. , Lah, James J. , Burns, Jeffrey M. , Silverman, Daniel H.S. , Johnson, Heather K. , Black, Sandra E. , Stefanovic, Bojana , Feldman, Howard , Martínez, Walter Fabián , Turner, Raymond Scott , Sperling, Reisa Anne , Rentz, Dorene M. , Johnson, Keith A. , Killiany, Ronald , Norbash, Alexander , Nair, Anil K. , Obisesan, Thomas O. , Wang, Paul C. , Fletcher, Evan M. , Carmichael, Owen , Bartha, Robert , Johnson, Sterling C. , Carlsson, Cynthia M. , Nguyen, Dana R. , Reeder, Stephanie, Scharre, Douglas W. , Pearlson, Godfrey D. , Sing, Kaycee M., Miller, Bruce L. , Jack, Clifford R , Preda, Adrian , Thompson, Paul M , Hsiung, Gink-Yuek
Neurology | January 22, 2015 | Volume: 84 | Issue: 7 | Pages: 729-737
The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Frisoni, Giovanni B. , Jack, Clifford R. , Bocchetta, Martina , Frederiksen, Kristian Steen , Liu, Yawu , Preboske, Gregory M., Swihart, Tim, Blair, Melanie , Cavedo, Enrica , Grothe, Michel J. , Lanfredi, Mariangela , Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis , Ward, Chadwich, Apostolova, Liana G. , Ganzola, Rossana , Barkhof, Frederik , Bartzokis, George, DeCarli, Charles , Csernansky, John G., deToledo‐Morrell, Leyla, Geerlings, Mirjam I. , Lehéricy, Stéphane , O’Brien, John T. , Silbert, Lisa C. , Scheltens, Philip , Waldemar, Gunhild, Fellgiebel, Andreas , Barnes, Josephine , Gerritsen, Lotte , Henneman, Wouter J.P., Malykhin, Nikolai , Pruessner, Jens C. , Watson, Craig, Leon, Mony J. de , Pantel, Johannes, Ferrari, Clarissa , Bosco, Paolo , Pasqualetti, Patrizio , Duchesne, Simon , Duvernoy, Henri M., Boccardi, Marina , Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Albert, Marilyn S. , Bennet, David, Camicioli, Richard , Collins, D. Louis , Dubois, Bruno , Hampel, Harald , denHeijer, Tom, Hock, Christofer, Jagust, William J. , Launer, Leonore J., Maller, Jerome J. , Mueller, S. G., Sachdev, Perminder S. , Simmons, Andy, Visser, Peter‐Jelle, Wahlund, Lars‐Olof , Weiner, Michael W. , Winblad, Bengt , Boccardi, Marina , Frisoni, Giovanni B. , DeCarli, Charles , Preboske, Gregory, Bauer, Corinna M. , Wolf, Dominik Georg Friedrich , Kaye, Jeffrey , Killiany, Ronald , Matsuda, Hiroshi , O'Brien, John Tiernan , Soininen, Hilkka S. , Teipel, Stefan Johannes , Waldemar, Gunhild , Firbank, Michael John , Wang, Lei , Wolf, Henrike , Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Thompson, Paul M. , Jack, Clifford R , Sachdev, Perminder S , Barkhof, Frederik , Scheltens, Philip , Wahlund, Lars-Olof , Grothe, Michel J , Bocchetta, Martina , Stoub, Travis
Alzheimer's & Dementia | September 27, 2014 | Volume: 11 | Issue: 2 | Pages: 111-125
10.1016/j.jalz.2014.05.1756
| PMID 25267715
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web‐platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). Conclusions The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
O2‐03‐01: INCREASED AMYLOID DEPOSITION IN OLDER ADULTS AT RISK FOR PROGRESSION TO ALZHEIMER'S DISEASE DUE TO GENETIC BACKGROUND AND/OR THE PRESENCE OF SIGNIFICANT MEMORY CONCERNS
West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Kim, Sungeun , Nho, Kwangsik T. , Wang, Yang , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_2 | Pages: No page available
P4‐298: IMPROVING THE POWER TO TRACK FIBRILLAR AMYLOID PET MEASUREMENTS AND EVALUATE AMYLOID‐MODIFYING TREATMENTS USING A CEREBRAL WHITE MATTER REFERENCE REGION‐OF‐INTEREST
Roontiva, Auttawut, Lee, Wendy , Ayutyanont, Napatkamon , Protas, Hillary , Landau, Susan , Luo, Ji , Bauer, Robert, Reschke, Cole, Bandy, Dan, Fleisher, Adam , Caselli, Richard J., Jagust, William J. , Weiner, Michael W. , Reiman, Eric M. , Chen, Kewei , Thiyyagura, Pradeep , Liu, Xiaofen , Koeppe, Robert A. , Caselli, Richard J.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_15 | Pages: No page available
IC‐P‐095: TWO‐YEAR LONGITUDINAL CHANGE IN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND HIPPOCAMPAL ATROPHY IN ADNI‐2 PARTICIPANTS: RELATION TO GENETIC RISK
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available
IC‐P‐096: INCREASED AMYLOID DEPOSITION IN OLDER ADULTS AT RISK FOR PROGRESSION TO ALZHEIMER'S DISEASE DUE TO GENETIC BACKGROUND AND/OR THE PRESENCE OF SIGNIFICANT MEMORY CONCERNS
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Wang, Yang , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available
O1‐07‐03: EFFECTS OF AMYLOID STATUS AND AGE ON LONGITUDINAL REGIONAL BRAIN ATROPHY IN ELDERLY HEALTHY CONTROLS
Nosheny, Rachel L. , Tosun, Duygu , Truran, Diana , Schuff, Norbert, Jagust, William, Petersen, Ronald C. , Aisen, Paul , Weiner, Michael W. , Insel, Philip S. , Mattsson, Niklas , Jack, Clifford R.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_1 | Pages: No page available
O3‐03‐02: TWO‐YEAR LONGITUDINAL CHANGE IN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND HIPPOCAMPAL ATROPHY IN ADNI‐2 PARTICIPANTS: RELATION TO GENETIC RISK
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Koeppe, Robert, Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Jack, Clifford R. , Saykin, Andrew J.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_3 | Pages: No page available