Citations
Mayo Clinic
2 citation(s) found for "Lyon, Zachary".
Demographic, Hemodynamic, Health-related Quality of Life, and Longitudinal Outcomes Differences Between Connective Tissue Disease-associated and Idiopathic PAH (Pulmonary Arterial Hypertension): The Pulmonary Hypertension Association Registry
Lyon, Zachary, Mathai, S.C. , Shlobin, Oksana A. , Marco, Teresa De , Mullin, Christopher J., Kolaitis, Nicholas A , Ventetuolo, Corey E. , Burger, Charles D. , Kawut, Steven M.
A97. IT'S (NOT) A SMALL WORLD: MOLECULAR AND PHYSIOLOGIC EPIDEMIOLOGY IN PAH | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A2753-A2753
The C Protein Is Recruited to Measles Virus Ribonucleocapsids by the Phosphoprotein
Pfaller, Christian K. , Bloyet, Louis-Marie , Donohue, Ryan C. , Bartemes, William P., Yousaf, Iris, Urzua, Érica, Clavière, Mathieu, Zachary, Marie , d’Autume, Valentin de Masson , Carson, Sandra E. , Schieferecke, Adam J. , Meyer, Alyssa J. , Gerlier, Denis , Cattaneo, Roberto , Huff, Amanda L. , Carson, Sandra, Gerlier, Denis , Cattaneo, Roberto , Pfaller, Christian K
Journal of Virology | November 18, 2019 | Volume: 94 | Issue: 4 | Pages: No page available
10.1128/jvi.01733-19
| PMID 31748390
Replication of negative-strand RNA viruses relies on two components: a helical ribonucleocapsid and an RNA-dependent RNA polymerase composed of a catalytic subunit, the L protein, and a cofactor, the P protein. We show that the measles virus (MeV) C protein is an additional component of the replication complex. We provide evidence that the C protein is recruited to the ribonucleocapsid by the P protein and map the interacting segments of both C and P proteins. We conclude that the primary function of MeV C is to improve polymerase processivity and accuracy, rather than uniquely to antagonize the type I interferon response. Since most viruses of the Paramyxoviridae family express C proteins, their primary function may be conserved.