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4 citation(s) found for "Kaczor, Mark".

Improving First-Attempt Success Rate During Neonatal Intubation in a Tertiary NICU
Kaczor, Mark , Wilhelm, Jayden, Bosley, Christopher, Schultz, Tammy, Schram, Laura, Gallup, Maria Cristina , Stetson, Raymond C. , Kaczor, Mark W., Brumbaugh, Jane E. , Wilhelm, Jayden M, Bosley, Christopher, Schultz, Tammy, Schram, Laura

Pediatrics | August 21, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1542/peds.2025-074216 | PMID 42624503 Get It

BACKGROUND AND OBJECTIVES Neonatal tracheal intubation is a high-risk procedure, and multiple attempts are associated with adverse events. At our tertiary neonatal intensive care unit, the baseline first-attempt success rate was 45%, which we aimed to increase to over 55% through a quality improvement (QI) initiative. METHODS A multidisciplinary team conducted a QI project using the define-measure-analyze-improve-control framework. Root cause analysis identified poor glottic visualization and patient instability as primary drivers of failure. Plan-do-study-act cycles were carried out (April 2023–July 2024), followed by a sustainability phase (August 2024–May 2025). Key interventions included the phased implementation of video laryngoscopy (VL) as the primary intubation device and the standardization of oxygenation during laryngoscopy using nasal high flow. First-attempt success was tracked using statistical process control, and bimonthly VL use was monitored as a process measure. RESULTS A total of 642 intubations were analyzed. By control chart analysis, the first-attempt success rate increased from a baseline of 45% to a sustained process mean of 61% during the intervention and sustainability phases. VL use increased from 0% at baseline to 70% to 90% during the sustainability phase. Success rates improved across all clinician types and locations. Notably, first-attempt success in infants weighing less than 1000 g increased from 38% at baseline to 62% during the intervention phase. CONCLUSION A systematic QI initiative focused on VL and standardized oxygenation improved and sustained neonatal intubation success rates, exceeding the project aim. The maintenance of high-success rates confirms the durability of these safety improvements.
Nasopharyngeal Swabs in Pediatric Patients With Thrombocytopenia and Anticoagulant Use
Greenmyer, Jacob R. , Kohorst, Mira A. , Kaczor, Mark , Alajbegovic, Katarina , Kranz, Lincoln A., Cain, Meghan, Ristagno, Elizabeth H. , Thompson, Whitney S.

Journal of Pediatric Hematology/Oncology | August 15, 2023 | Volume: 45 | Issue: 7 | Pages: e910-e914

10.1097/mph.0000000000002741 | PMID 37582659 Get It

Background: Nasopharyngeal (NP) swabbing is a technique that is commonly used to test pediatric patients for viral infections with increased use during the coronavirus disease 2019 pandemic. Complications from NP swabbing are rare and seem to occur more frequently in patients at risk of bleeding. Little is known about institutional or individual practices and experiences with NP swab testing in pediatric patients with risk factors for bleeding. Methods: We conducted a survey study of pediatric hematology/oncology (PHO) attending physicians to assess practices and experiences with NP swab testing in pediatric patients with thrombocytopenia and/or on anticoagulation. Results: There were 130 total respondents (5.6%, n = 130/2327) from 6 countries. Relatively few respondents (n = 17/130, 13.1%) reported that their institution had a policy specifying a lower-level platelet cutoff for patients undergoing NP swabbing. The median platelet cutoff below which NP swabs are not performed according to existing policies is 30,000×10(9)/L (interquartile range: 20,000 to 40,000). The median cutoff based on the opinion of the respondents was 10,000 (interquartile range: 10,000 to 20,000). There were 24 episodes of epistaxis among PHO patients that were NP swabbed; many adverse events (56.5%, n = 13/23) were described as persistent, severe, and/or required intervention. Three reported cases of epistaxis with anticoagulation or antiplatelet therapy occurred in patients with concomitant thrombocytopenia. Only 1 respondent (n = 1/130, 0.7%) reported an institutional policy for limiting NP swabs in patients on anticoagulant therapy. NP (66.9%) and nares (33.1%) were the most common sources of coronavirus disease 2019 testing that were reported. Conclusion: A small percentage of institutions in this survey have a policy restricting NP swabs in PHO patients. The discrepancy between lower platelet cutoffs proposed by experts and institutional policy suggests that existing policies may be too conservative. Expert guidelines are needed on this topic. Other bleeding risk factors (eg, aspirin use and von Willebrand disease) should be considered in policies and guidelines.
A comparison of human natural monoclonal antibodies and aptamer conjugates for promotion of CNS remyelination: where are we now and what comes next?
Perwein, Maria Katharina Elisabeth , Smestad, John , Warrington, Arthur E. , Heider, Robin M., Kaczor, Mark W., Maher, L. James , Wootla, Bharath , Kunbaz, Ahmad , Rodriguez, Moses , Perwein, Maria K, Smestad, John A, III, Louis James Maher , Wootla, Bharath , Rodriguez, Moses , Smestad, John

Expert Opinion on Biological Therapy | February 23, 2018 | Volume: 18 | Issue: 5 | Pages: 545-560

10.1080/14712598.2018.1441284 | PMID 29460650 Get It

Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease
Marinelli, John P. , Link, Michael J., Moore, Eric J. , Lees, Katherine A. , Kaczor, Mark W., Janus, Jeffrey R. , Gompel, Jamie J. Van , Price, Daniel L.

The Laryngoscope | August 22, 2017 | Volume: 128 | Issue: 4 | Pages: 864-870

10.1002/lary.26843 | PMID 28833165 Get It

ObjectiveTo determine if the laterality of primary tumors in patients with olfactory neuroblastoma (ONB) influenced the pattern and development of neck disease.MethodsUsing a retrospective cohort study design from 1994 to 2015, the primary tumors of patients who either presented with or developed neck disease were volumetrically analyzed using iPlan software (version 3.0.0, BrainLAB, Feldkirchen, Germany) by two independent observers. Agreement of volume‐derived sidedness was assessed with a kappa statistic, whereas agreement in volume‐derived degree of tumor laterality was evaluated with an intraclass correlation coefficient. A one‐sample t test was used to assess the difference in dominant percentage between the two observers.ResultsSixty‐one patients with histological diagnosis and treatment of ONB at our institution were identified. Twenty‐four patients exhibited neck involvement, 13 of whom could be volumetrically analyzed. Tumors that were greater than 75% eccentric to one side all exhibited contralateral disease, whereas the majority of unilateral neck disease was associated with relatively midline masses. Within the entire cohort, ipsilateral level 2 lymph nodes displayed the highest involvement (83%, 20 of 24), followed by ipsilateral level 1 (54%, 13 of 24), contralateral level 2 (46%, 11 of 24), contralateral level 1 (21%, 5 of 24), and ipsilateral level 3 (21%, 5 of 24).ConclusionIpsilateral neck involvement frequently was observed; however, the degree of ONB primary site laterality did not appear to have implications on the development of contralateral neck disease. Therefore, when considering elective therapy to the neck, ONB laterality should not be used to justify unilateral neck treatment.Level of Evidence4. Laryngoscope, 128:864–870, 2018