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189 citation(s) found for "Aisen, Paul".

Longitudinal decline in mild‐to‐moderate Alzheimer's disease: Analyses of placebo data from clinical trials
Thomas, Ronald G. , Albert, Marilyn, Petersen, Ronald C. , Aisen, Paul

Alzheimer's & Dementia | February 23, 2016 | Volume: 12 | Issue: 5 | Pages: 598-603

10.1016/j.jalz.2016.01.002 | PMID 26917500 Get It

AbstractIntroductionAccurate estimates of cognitive and clinical decline rates are essential to the design of clinical trials in Alzheimer's disease (AD) dementia.MethodsTo investigate the trajectories of individuals enrolled in therapeutic trials in mild‐to‐moderate AD, we analyzed the placebo arm data from 20 clinical trials including over 4500 subjects. We analyzed decline as measured by two cognitive instruments, the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAScog) and the Mini‐Mental State Examination, and one clinical rating scale, the Clinical Dementia Rating Sum of Boxes.ResultsTrajectories were generally similar across trials and nearly linear. Greater cognitive impairment at baseline, younger age, and greater education were associated with increased rate of cognitive decline. Effect sizes for the ADAScog were generated as a function of population characteristics.DiscussionThese data will inform the design of future studies of potential disease‐modifying therapies for mild‐to‐moderate AD dementia.
IC‐P‐034: Anticholinergic medication use in older adults is associated with memory and hippocampal volume
Kim, Sungeun , Aisen, Paul, Petersen, Ronald , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Nho, Kwangsik T. , Shen, Li , Crane, Paul K. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.054 Get It

O4‐05‐01: Gwas of longitudinal amyloid PET identifies IL1RAP as a new potential Alzheimer's disease target
Kim, Sungeun , Aisen, Paul, Petersen, Ronald C. , Jagust, William J. , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Ramanan, Vijay K. , Risacher, Shannon L. , Nho, Kwangsik T. , Shen, Li , Foroud, Tatiana , Toga, Arthur W. , Green, Robert C. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2015.07.369 Get It

P3‐014: Influence of rare RELN variants on quantitative PET imaging and CSF phenotypes in late‐onset Alzheimer's disease
Aisen, Paul, Petersen, Ronald , Jagust, William J. , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Greicius, Michael D. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Foroud, Tatiana , Jack, Clifford R. , Trojanowski, John Q., Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_13 | Pages: No page available

10.1016/j.jalz.2015.06.880 Get It

P1‐193: Anticholinergic medication use in older adults is associated with memory and hippocampal volume
Kim, Sungeun , Aisen, Paul, Petersen, Ronald , Weiner, Michael W. , (ADNI), the Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Nho, Kwangsik T. , Shen, Li , Crane, Paul K. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_9 | Pages: No page available

10.1016/j.jalz.2015.06.392 Get It

IC‐P‐042: Influence of rare reelin variants on quantitative PET imaging and CSF phenotypes in late‐onset Alzheimer's disease
Aisen, Paul, Petersen, Ronald , Jagust, William J. , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Greicius, Michael D. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Foroud, Tatiana , Jack, Clifford R. , Trojanowski, John Q., Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.062 Get It

P1‐319: Alzheimer's prevention registry: A shared resource to the scientific community to facilitate enrollment in studies
High, Nellie, Reiman, Eric M. , Aisen, Paul, Albert, Marilyn S. , Comer, Meryl, Petersen, Ronald , Strobel, Gabrielle, Weiner, Michael W. , Tariot, Pierre N. , Langbaum, Jessica B. S. , Cummings, Jeffrey L. , Manly, Jennifer J. , Sperling, Reisa Anne

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_10 | Pages: No page available

10.1016/j.jalz.2015.06.534 Get It

IC‐P‐037: Association of cerebral microhemorrhages with amyloid deposition and hyperlipidemia
Kim, Sungeun , Jagust, William J. , Aisen, Paul, Petersen, Ronald C. , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Nho, Kwangsik T. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.057 Get It

IC‐P‐036: Association of eye disease with increased diffusivity in the sagittal stratum
Contreras, Joey A. , West, John D. , Gao, Sujuan , Aisen, Paul, Petersen, Ronald C. , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Shen, Li , Goñi, Joaquín , Thompson, Paul M. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.056 Get It

IC‐P‐035: Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities
West, John D. , Zheng, Yuese, Kim, Sungeun , Aisen, Paul , Petersen, Ronald C. , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Shen, Li , Nho, Kwangsik T. , Crane, Paul K. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.055 Get It