Citations 3
Relationships between big‐five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease
Aschenbrenner, Andrew J. , Petros, Jennifer, Wang, Guoqiao , Balota, David A., Cruchaga, Carlos , Goate, Alison , Xiong, Chengjie , Perrin, Richard J. , Fagan, Anne M. , Graff‐Radford, Neill, Weidinger, Endy , Gräber, Susanne, Chhatwal, Jasmeer P. , Morris, John C. , Bateman, Randall J. , Hassenstab, Jason , Network, for the Dominantly Inherited Alzheimer, Cruchaga, Carlos , Bateman, Randall J , Xiong, Chengjie , Hassenstab, Jason , Morris, John C , Aschenbrenner, Andrew J , Goate, Alison M , McDade, Eric , Benzinger, Tammie L.S. , Xiong, Chengjie , Graff‐Radford, Neill, Ghetti, Bernardino , Schofield, Peter R. , Lee, Jae‐Hong , Network, for the Dominantly Inherited Alzheimer
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | June 24, 2020 | Volume: 12 | Issue: 1 | Pages: No page available
Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)
Aschenbrenner, Andrew J. , James, Bryan D. , Wang, Guoqiao , Lim, Yen Ying , Benzinger, Tammie L.S. , Cruchaga, Carlos , Goate, Alison , Xiong, Chengjie , Perrin, Richard J. , Buckles, Virginia, Berman, Sarah , Chhatwal, Jasmeer P. , Fagan, Anne M. , Farlow, Martin R. , O’Connor, Antoinette , Graff‐Radford, Neill R. , Gräber, Susanne, Martins, Ralph N. , Masters, Colin L. , Mori, Hiroshi , Noble, James M. , Salloway, Stephen , Morris, John C. , Bateman, Randall J. , Hassenstab, Jason , Network, Dominantly Inherited Alzheimer, Cruchaga, Carlos , O'Connor, Antoinette , Bateman, Randall J , Masters, Colin L , Xiong, Chengjie , Benzinger, Tammie L S , Hassenstab, Jason , Morris, John C , Aschenbrenner, Andrew J , Goate, Alison M , Berman, Sarah , McDade, Eric , Xiong, Chengjie , Allegri, Ricardo , Ghetti, Bernardino , Goldman, Jill , Karch, Celeste M. , Lee, Jae‐Hong , Schofield, Peter R. , Network, Dominantly Inherited Alzheimer, Noble, James M
Alzheimer's & Dementia | January 16, 2020 | Volume: 16 | Issue: 1 | Pages: 219-228
AbstractIntroductionAlthough some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is unknown. This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers.MethodsMutation carriers and non‐carriers from the Dominantly Inherited Alzheimer Network (DIAN) were stratified based on knowledge of mutation status. Rates of change on standard clinical, cognitive, and neuroimaging outcomes were examined.ResultsMutation knowledge had no associations with cognitive decline, clinical progression, amyloid deposition, hippocampal volume, or depression in either carriers or non‐carriers. Carriers who learned their status mid‐study had slightly higher levels of depression and lower cognitive scores.DiscussionKnowledge of mutation status does not affect rates of change on any measured outcome. Learning of status mid‐study may confer short‐term changes in cognitive functioning, or changes in cognition may influence the determination of mutation status.
Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease
Preische, Oliver, Sohrabi, Hamid R. , Gräber, Susanne, Ringman, John M. , Martins, Ralph N. , Rossor, Martin N. , Fox, Nick N., Graff‐Radford, Neill R. , Xiong, Chengjie , Danek, Adrian , Vöglein, Jonathan , Salloway, Stephen , Xiong, Chengjie , Benzinger, Tammie L.S. , Buckles, Virginia, Masters, Colin L. , Bateman, Randall J. , Morris, John C. , Laske, Christoph , (DIAN), Dominantly Inherited Alzheimer Network, Fox, Nick C. , Bateman, Randall J , Masters, Colin L , Vöglein, Jonathan , Xiong, Chengjie , Benzinger, Tammie L S , Fox, Nick C , Morris, John C , Müller, Stephan, Jucker, Mathias , McDade, Eric , Schofield, Peter R. , Ghetti, Bernardino , Fox, Nick N., Sperling, Reisa Anne , (DIAN), Dominantly Inherited Alzheimer Network
Alzheimer's & Dementia | September 25, 2018 | Volume: 14 | Issue: 11 | Pages: 1427-1437
AbstractIntroductionLittle is known about effects of physical activity (PA) in genetically driven early‐onset autosomal dominant Alzheimer's disease (AD).MethodsA total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross‐sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.ResultsMutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD‐like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.DiscussionThese results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.