Tirode, Franck
https://orcid.org/0000-0003-4731-7817
Mayo Clinic
Centre de Recherche en Cancérologie de Lyon
Citations 2
Author response: tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish
Hayes, Madeline N. , Moore, Finola E., Tang, Qin , Blackburn, Patrick R. , Ramakrishnan, Ashwin , Reeder, Sophia M. , Nielsen, G. Petur , Hasserjian, Robert P. , Langenau, David M. , Ignatius, Myron S. , Garcia, Sara P. , Baxi, Kunal , Wang, Long, Jin, Alexander , Chen, Yidong , Chen, Eleanor Y. , Tirode, Franck , Ekker, Stephen C.
No container title available | September 7, 2018 | Volume: No volume available | Issue: No issue available | Pages: No page available
tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish
Hayes, Madeline N. , Moore, Finola E., Tang, Qin , Blackburn, Patrick R. , Baxi, Kunal , Wang, Long , Jin, Alexander , Ramakrishnan, Ashwin , Reeder, Sophia M. , Nielsen, G. Petur , Hasserjian, Robert P. , Tirode, Franck , Ekker, Stephen C. , Langenau, David M. , Tang, Qin , Blackburn, Patrick , Tirode, Franck , Ekker, Stephen C , Langenau, David M , Ignatius, Myron S. , Garcia, Sara P. , Chen, Yidong , Chen, Eleanor Y.
eLife | September 7, 2018 | Volume: 7 | Issue: No issue available | Pages: No page available
The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive Natural Killer cell-like leukemia for which no animal model has been developed. Because the tp53 deletion was generated in syngeneic zebrafish, engraftment of fluorescent-labeled tumors could be dynamically visualized over time. Importantly, engrafted tumors shared gene expression signatures with predicted cells of origin in human tissue. Finally, we showed that tp53del/del enhanced invasion and metastasis in kRASG12D-induced embryonal rhabdomyosarcoma (ERMS), but did not alter the overall frequency of cancer stem cells, suggesting novel pro-metastatic roles for TP53 loss-of-function in human muscle tumors. In summary, we have developed a Li-Fraumeni zebrafish model that is amenable to large-scale transplantation and direct visualization of tumor growth in live animals.