Wood, Trevor

BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is the standard operative approach for ulcerative colitis (UC) or inflammatory bowel disease unclassified (IBDu) patients with medical refractory disease or dysplasia. Pouchitis or denovo Crohn’s disease are frequent adverse outcomes. The presence of small bowel (SB) mucosal inflammation before surgery might be an important predictor of these outcomes after surgery. Although small bowel follow through (SBFT) with barium has been the traditional imaging modality, cross sectional imaging using CT enterography (CTE) or MR enterography (MRE) have become increasingly utilized for preoperative SB assessment. The aim of this study was to assess changes in the utilization of SBFT versus CTE/MRE in UC and IBDu patients undergoing IPAA. METHODS: Prospectively generated clinical profiles on consecutive UC and IBDu patients undergoing IPAA between November 2006 and August 2019 were reviewed. Patients were classified into 2 groups: Group A (2006-2012) and Group B (2013-2019). Each patient was evaluated for preoperative SB imaging within their respective group. Baseline demographics were compared between groups. Imaging modalities included SBFT, CTE, MRE or ‘no imaging’. RESULTS: The study cohort of 354 patients had a mean age of 37.3 years (SD 17.1) years and included 50% males. Group A included 196 (55%) patients and Group B included 158 (45%) patients. Groups were comparable in terms of age, gender, and indication for surgery. Patients in Group A had a significantly longer disease duration (115 vs 85 months, P = 0.01) and greater number of IBDU patients (37% vs 22%, P < 0.01) versus UC patients (64% vs 77%, P < 0.01). When comparing imaging modalities, there was a significantly higher use of SBFT in Group A (44% vs 4%, P < 0.01), significantly higher use of CTE and MRE in Group B (11% vs 27%, P < 0.01 and 7% vs 40%, P < 0.01, respectively), and no difference in ‘no imaging’ between the two groups (32% vs 29%, P = 0.56). CONCLUSION(S): Cross sectional imaging using CTE or MRE has become the preferred modality of preoperative SB imaging in UC and IBDu patients undergoing IPAA.

Background and Objectives Patients with colorectal cancer with synchronous liver metastases may undergo a staged or a simultaneous resection. This study aimed to determine whether the time to adjuvant chemotherapy was delayed in patients undergoing a simultaneous resection. Methods A retrospective cohort study was conducted between 2005 and 2016. The primary outcome was time to adjuvant chemotherapy. A multivariate linear regression was conducted to ascertain the adjusted effect of a simultaneous versus a staged approach on time to adjuvant chemotherapy. Results A total of 155 patients were included. A total of 127 patients underwent a staged resection, whereas 28 patients underwent a simultaneous resection. Age, sex, and American Society of Anesthesiologists class as well tumor, node, metastasis stage, tumor location, and number and size of metastases were not significantly different between the groups. The median time to adjuvant chemotherapy was 70 and 63 days for the staged and simultaneous groups, respectively ( P = .27). Multivariate analysis did not demonstrate an increased propensity for prolonged time to chemotherapy after simultaneous resection (rate ratio: 0.97, 95% CI: 0.71‐1.32, P = .84). There were no significant differences in the length of stay, complications, overall survival, and disease‐free survival between the groups ( P > .05). Conclusions This study demonstrated that simultaneous resection does not result in significant delay of adjuvant chemotherapy compared with a staged approach.