Citations 1
Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder
Li, Jiao , Ruskey, Jennifer A. , Arnulf, Isabelle , Dauvilliers, Yves , Hu, Michele T.M., Högl, Birgit , Leblond, Claire S. , Ambalavanan, Amirthagowri , Ross, Jay P. , Bourassa, Cynthia V., Spiegelman, Dan , Laurent, Sandra B., Stefani, Ambra , Monaca, Christelle, Boivin, Michel , Antelmi, Elena , Young, Peter, Heidbreder, Anna , Ferman, Tanis J. , Dion, Patrick A. , Désautels, Alex , Gagnon, Jean‐François, Dupré, Nicolas , Montplaisir, Jacques , Boeve, Bradley F., Ross, Owen A. , Shulman, Joshua , Labbé, Catherine, Antelmi, Elena , Ross, Owen A , Dauvilliers, Yves , Ferman, Tanis J , Stefani, Ambra , Zhou, Sirui , Cochen De Cock, Valérie , Ferini-Strambi, Luigi , Plazzi, Giuseppe , Labbé, Catherine , Fan, Dongsheng , Fon, Edward A , Boeve, Bradley F. , Postuma, Ronald B. , Rouleau, Guy Armand , Gan‐Or, Ziv , Arnulf, Isabelle , Hu, Michele T M , Högl, Birgit , Heidbreder, Anna
Movement Disorders | May 14, 2018 | Volume: 33 | Issue: 6 | Pages: 1016-1020
ABSTRACT Background: MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear. Objective: To study the role of MAPT variants in rapid eye movement sleep behavior disorder. Methods: Two cohorts were included: (A) PD (n = 600), rapid eye movement sleep behavior disorder (n = 613) patients, and controls (n = 981); (B) dementia with Lewy bodies patients with rapid eye movement sleep behavior disorder (n = 271) and controls (n = 950). MAPT ‐associated variants and the entire coding sequence of MAPT were analyzed. Age‐, sex‐, and ethnicity‐adjusted analyses were performed to examine the association between MAPT , PD, and rapid eye movement sleep behavior disorder. Results: MAPT‐ H2 variants were associated with PD (odds ratios: 0.62‐0.65; P = 0.010‐0.019), but not with rapid eye movement sleep behavior disorder. In PD, the H1 haplotype odds ratio was 1.60 (95% confidence interval: 1.12‐2.28; P = 0.009), and the H2 odds ratio was 0.68 (95% confidence interval: 0.48‐0.96; P = 0.03). The H2/H1 haplotypes were not associated with rapid eye movement sleep behavior disorder. Conclusions: Our results confirm the protective effect of the MAPT ‐H2 haplotype in PD, and define its components. Furthermore, our results suggest that MAPT does not play a major role in rapid eye movement sleep behavior disorder, emphasizing different genetic background than in PD in this locus. © 2018 International Parkinson and Movement Disorder Society