Citations 2
Gastrointestinal Tract Disorders in Older Age
Dumic, Igor , Nordin, Terri , Jecmenica, Mladen , Lalošević, Milica Stojković , Milosavljević, Tomica , Alempijević, Tamara , Stojkovic Lalosevic, Milica , Alempijevic, Tamara , Dumic, Igor
Canadian Journal of Gastroenterology and Hepatology | January 17, 2019 | Volume: 2019 | Issue: No issue available | Pages: 1-19
Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging. Gastrointestinal (GI) changes in the elderly are common, and despite some GI disorders being more prevalent in the elderly, there is no GI disease that is limited to this age group. While some changes associated with aging GI system are physiologic, others are pathological and particularly more prevalent among those above age 65 years. This article reviews the most important GI disorders in the elderly that clinicians encounter on a daily basis. We highlight age-related changes of the oral cavity, esophagus, stomach, small and large bowels, and the clinical implications of these changes. We review epidemiology and pathophysiology of common diseases, especially as they relate to clinical manifestation in elderly. Details regarding management of specific disease are discussed in detail if they significantly differ from the management for younger groups or if they are associated with significant challenges due to side effects or polypharmacy. Cancers of GI tract are not included in the scope of this article.
Diagnostic Accuracy of Platelet Count and Platelet Indices in Noninvasive Assessment of Fibrosis in Nonalcoholic Fatty Liver Disease Patients
Alempijević, Tamara , Dumic, Igor , Jocic, Nevena, Marković, Aleksandra Pavlović , Dragašević, Sanja , Jovicic, Ivana, Lukić, Snežana , Milosavljević, Tomica , Dumic, Igor , Alempijevic, Tamara , Lalošević, Milica Stojković , Popović, Dragan
Canadian Journal of Gastroenterology and Hepatology | December 31, 2017 | Volume: 2017 | Issue: No issue available | Pages: 1-5
Objective. Keeping in mind the rising prevalence of nonalcoholic fatty liver disease (NAFLD) and the need to establish noninvasive tests for its detection, the aim of our study was to investigate whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) can predict the presence of liver fibrosis in this group of patients. Methods. In 98 patients with NAFLD and 60 healthy volunteers, complete blood counts with automated differential counts were performed and values of PC, PDW, MPV, and PCT were analyzed. Results. Patients with NAFLD had lower PC and higher MPV, PCT, and PDW compared to the controls (P < 0.05). When NAFLD group was stratified according to severity of liver fibrosis, there was a statistically significant difference in the average values of PDW and PC between the groups (P < 0.05). Conclusion. Patients with NAFLD have significantly higher values of PCT, PDW, and MPV when compared to the healthy controls. Further studies are needed to establish their potential use for prediction of the degree of liver steatosis and fibrosis in NAFLD patients.