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Hoeffner, U.

Mayo Clinic

Glenmark Pharmaceuticals, Gröbenzell, Germany (U.H.)

Citations 3

Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019)
Baretella, Oliver , Blaise, Gilbert, Bond, Richard A. , Cai, Yin , Chan, C K, Chataigneau, Thierry, Chen, M., Chen, Hui , Cheng, Yanhua, Clément, Denis, Cohen, Richard A. , Collis, Michael J., Detremmerie, Charlotte Marie Simonne, Félétou, Michel, Flavahan, Nicolas, Gao, Yuansheng, Guo, Yumeng , Hoeffner, U., Houston, Donald S., Huang, Ianto Boscheng, Huang, Yü , Iliano, Stephane, Junquéro, Didier, Katušić, Zvonimir S. , Komori, Kimihiro , Lee, Mary Y. K. , Leung, Susan W.S. , Li, Zhuo-ming, Liang, Sophie Chaofan, Liu, J, Lüscher, Thomas F. , Michel, Frederic, Miller, Virginia M. , Mombouli, Jean-Vivien, Morrison, Keith , Muldoon, Sheila M., O’Rourke, Steve, Perrault, Louis P. , Quignard, Jean‐François , Rusch, Nancy J. , Sánchez‐Ferrer, Carlos F. , Shen, Kaikai , Shi, Yi , Song, Erfei , Sun, Kiwi W.Y., Tang, Eva Hoi Ching, Tuncer, Meral , Ende, Romana van den, Vedernikov, Yuri P., Verbeuren, Tony J., Webb, Clinton, Wong, Kenneth H.K., Xu, Cheng , Yang, Kangmin , Zellers, Thomas M. , Zhao, Yingzi , Zou, Qian , fellows, on behalf of Professor Paul M. Vanhoutte’s former, Boulanger, Chantal M. , Collis, Michael, Danser, A.H. Jan , Mey, Jo G. R. De , Duprez, Daniel , Huang, Ianto Bosheng , Michel, Frederic, Schini‐Kerth, Valérie B. , Shi, Yi, Taddei, Stefano , Tang, Eva H.C., Weigert, André Luiz Loureiro , Wong, Kenneth K. H., Ying, Fan, Shimokawa, Hiroaki , fellows, on behalf of Professor Paul M. Vanhoutte’s former

Arteriosclerosis, Thrombosis, and Vascular Biology | November 26, 2019 | Volume: 39 | Issue: 12 | Pages: 2445-2447

10.1161/atvbaha.119.313461 Get It

Canine arteries release two different endothelium-derived relaxing factors
Hoeffner, U., Félétou, Michel, Flavahan, Nicholas A. , Vanhoutte, PM

American Journal of Physiology-Heart and Circulatory Physiology | December 21, 2017 | Volume: 257 | Issue: 1 | Pages: H330-H333

10.1152/ajpheart.1989.257.1.h330 Get It

Experiments were designed to analyze the effects of ouabain on the response of vascular smooth muscle to endothelium-derived relaxing factors released under basal conditions and on stimulation with acetylcholine or bradykinin. Bioassay rings of canine coronary artery (without endothelium) were superfused with perfusate from canine left circumflex coronary arteries with endothelium (donor arteries). During contractions of the bioassay ring evoked by prostaglandin F2 alpha, the relaxations caused by endothelium-derived relaxing factor(s), released under basal conditions or on exposure of the endothelial cells of the donor artery to maximally effective concentrations of acetylcholine, were reduced by incubation of the bioassay ring with ouabain. However, the relaxations evoked by infusion of bradykinin were not altered by incubation of the bioassay rings with ouabain. These experiments demonstrate the release of two endothelium-derived relaxing factors that can be distinguished using ouabain.
Proximal and distal dog coronary arteries respond differently to basal EDRF but not to NO
Hoeffner, U., Vanhoutte, Paul M. , Boulanger, Chantal M.

American Journal of Physiology-Heart and Circulatory Physiology | December 21, 2017 | Volume: 256 | Issue: 3 | Pages: H828-H831

10.1152/ajpheart.1989.256.3.h828 Get It

Experiments were designed to analyze the effects of endothelium-derived relaxing factor(s) (EDRF; released basally or on stimulation with acetylcholine) and nitric oxide (NO) on smooth muscle of coronary arteries of different diameter. During contractions of the bioassay ring evoked with prostaglandin F2 alpha, the relaxations caused by basal EDRF were greater in the distal than in the proximal coronary arteries, whereas there was no difference in response to the EDRF released by acetylcholine. During direct superfusion, NO caused similar relaxations in proximal and distal coronary artery rings. Optimal tension, prostaglandin F2 alpha-induced contractions, and relaxations caused by sodium nitroprusside were comparable in both preparations. In rings of proximal and distal coronary artery studied in organ chambers, acetylcholine caused comparable endothelium-dependent, whereas sodium nitroprusside and NO cause comparable endothelium-independent relaxations. These experiments indicate a difference in response of different-sized coronary arteries to basally released EDRF and suggest that the basally released factor differs from NO.