Citations 1
Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations
Durham, Benjamin H. , Getta, Bartlomiej , Won, Helen , Scott, Sasinya N., Chung, Young Rock , Chung, Stephen S. , Hüllein, Jennifer , Walther, Tatjana, Wang, Lu , Oakes, Christopher C. , Tibes, Raoul , Haferlach, Torsten , Taylor, Barry S. , Tallman, Martin S. , Park, Jae H. , Bogenberger, James M. , Abdel-Wahab, Omar , Dietrich, Sascha , Taylor, Justin , Kim, Eun Hee , Lu, Sydney X. , Berger, Michael , Zenz, Thorsten , Abdel‐Wahab, Omar , Durham, Benjamin
Blood | August 11, 2017 | Volume: 130 | Issue: 14 | Pages: 1644-1648
Key Points KMT2C mutations occur in 15% and 25% of patients with cHCL and vHCL, respectively, along with CCND3 and U2AF1 mutations each in 13% of vHCLs. NF1, NF2, N/KRAS, and IRS1 alterations contribute to clinical resistance to vemurafenib treatment in patients with cHCL.