Citations 2
Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function
Franks, Teri J. , Colby, T. V., Travis, W. D., Tuder, Rubin M. , Reynolds, Herbert Y., Brody, Arnold R., Cardoso, Wellington V. , Crystal, R G , Drake, Christopher J., Engelhardt, John F. , Frid, M., Herzog, E. , Mason, R., Phan, Sem H. , Randell, Scott H. , Rose, Mary C., Stevens, T., Serge, J., Sunday, Mary E. , Voynow, Judith A. , Weinstein, Brant M. , Whitsett, J., Williams, Mary C., Williams, Mary C.
Proceedings of the American Thoracic Society | August 28, 2008 | Volume: 5 | Issue: 7 | Pages: 763-766
Abstract The purpose of the workshop was to identify still obscure or novel cellular components of the lung, to determine cell function in lung development and in health that impacts on disease, and to decide promising avenues for future research to extract and phenotype these cells. Since robust technologies are now available to identify, sort, purify, culture, and phenotype cells, progress is now within sight to unravel the origins and functional capabilities of lung cells in developmental stages and in disease. The Workshop's agenda was to first discuss the lung's embryologic development, including progenitor and stem cells, and then assess the functional and structural cells in three main compartments of the lung: (1) airway cells in bronchial and bronchiolar epithelium and bronchial glands (basal, secretory, ciliated, Clara, and neuroendocrine cells); (2) alveolar unit cells (Type 1 cells, Type 2 cells, and fibroblasts in the interstitium); and (3) pulmonary vascular cells (endothelial cells from different vascular structures, smooth muscle cells, and adventitial fibroblasts). The main recommendations were to: (1) characterize with better cell markers, both surface and nonsurface, the various cells within the lung, including progenitor cells and stem cells; (2) obtain more knowledge about gene expression in specific cell types in health and disease, which will provide insights into biological and pathologic processes; (3) develop more methodologies for cell culture, isolation, sorting, co-culture, and immortalization; and (4) promote tissue banks to facilitate the procurement of tissue from normal and from diseased lung for analysis at all levels.
Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases
Voynow, Judith A. , Gendler, Sandra , Rose, Mary C.
American Journal of Respiratory Cell and Molecular Biology | February 2, 2006 | Volume: 34 | Issue: 6 | Pages: 661-665
Abstract In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.