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Freedman, Robert I.

Mayo Clinic

Denver VA Medical Center

Citations 1

Partial Resolution of Tardive Dyskinesia with Treatment of Co-existing Thyrotoxicosis *
Leder, Robert, Kirch, Darrell G., Clay, Keith L., Freedman, Robert I., Murphy, Robert C.

The Canadian Journal of Psychiatry | April 26, 2017 | Volume: 28 | Issue: 2 | Pages: 134-136

10.1177/070674378302800212 Get It

Neuroleptic-induced tardive dyskinesia improved after treatment of thyrotoxicosis. Neuroleptic blood levels indicated that the improvement was not caused by masking of the symptoms by rising drug levels. Dopamine metabolite measurements suggested that the thyrotoxicosis caused an increase in the sensitivity of caudate neurons to dopamine, rather than a change in release of dopamine.