Citations 1
Eosinophils, but Not Eosinophil Peroxidase or Major Basic Protein, Are Important for Host Protection in ExperimentalBrugia pahangiInfection
Ramalingam, Thirumalai R. , Porte, Patricia, Lee, James , Rajan, T. V.
Infection and Immunity | November 18, 2005 | Volume: 73 | Issue: 12 | Pages: 8442-8443
10.1128/iai.73.12.8442-8443.2005
ABSTRACTThe attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitonealBrugia pahangiinfections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.