Citations 1
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
Tasian, Sarah K. , Shen, Feng , Ruella, Marco , Shestova, Olga, Kozlowski, Miroslaw , Schrank-Hacker, April M., June, Carl H. , Gill, Saar , Kenderian, Saad S. , Li, Yong, Morrissette, Jennifer J. D. , Carroll, Martin P , Grupp, Stephan A. , Ruella, Marco
Blood | February 28, 2017 | Volume: 129 | Issue: 17 | Pages: 2395-2407
Key Points Depletion of CD123-redirected CAR T cells with monoclonal antibodies preserves leukemia remission in human AML xenograft models. AML CAR T-cell depletion enhances feasibility of subsequent allogeneic stem cell transplantation.