Citations 2
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline
LeRoith, Derek, Biessels, Geert Jan , Braithwaite, Susan S., Draznin, Boris , Halter, Jeffrey B., McDonnell, Marie E. , Molitch, Mark E. , Murad, M. Hassan , Murad, M Hassan , McDonnell, Marie E , Biessels, Geert Jan , Casanueva, Felipe F. , Hirsch, Irl B. , Sinclair, Alan J.
The Journal of Clinical Endocrinology & Metabolism | March 23, 2019 | Volume: 104 | Issue: 5 | Pages: 1520-1574
Abstract Objective The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more prevalent in the general population, especially in individuals over the age of 65 years. The underlying pathophysiology of the disease in these patients is exacerbated by the direct effects of aging on metabolic regulation. Similarly, aging effects interact with diabetes to accelerate the progression of many common diabetes complications. Each section in this guideline covers all aspects of the etiology and available evidence, primarily from controlled trials, on therapeutic options and outcomes in this population. The goal is to give guidance to practicing health care providers that will benefit patients with diabetes (both type 1 and type 2), paying particular attention to avoiding unnecessary and/or harmful adverse effects.
Disease drivers of aging
Hodes, Richard J. , Sierra, Felipe , Austad, Steven N. , Epel, Elissa S. , Schafer, Marissa , LeBrasseur, Nathan K. , Wiley, Christopher D. , Campisi, Judith , Sehl, Mary E. , Scalia, Rosario , Eguchi, Satoru , Kasinath, Balakuntalam S. , Halter, Jeffrey B., Cohen, Harvey Jay, Demark‐Wahnefried, Wendy , Ahles, Tim A. , Barzilai, Nir , Hurria, Arti , Hunt, Peter W. , Schafer, Marissa J, Neigh, Gretchen N. , Erlandson, Kristine M. , LeBrasseur, Nathan K , Schafer, Marissa J , Demark-Wahnefried, Wendy
Annals of the New York Academy of Sciences | December 14, 2016 | Volume: 1386 | Issue: 1 | Pages: 45-68
It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship—the contribution of chronic diseases and their treatments to the progression of aging‐related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.