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Webb, J. L.

0000-0003-1657-6445

Mayo Clinic

Iowa State University

Citations 6

[IC‐P‐066]: AD FAMILY HISTORY MODULATES EFFECTS OF TOMM40 ‘523’ POLY‐T ON MTL ATROPHY AND HYPOMETABOLISM IN PRECLINICAL AND AD COHORTS
Willette, Auriel A. , Webb, J. L. , Oh, Jennifer M. , Roses, Allen D., Koscik, Rebecca L. , Asthana, Sanjay , Lutz, Michael W. , Bendlin, Barbara B. , Wennberg, Alexandra , Hermann, Bruce P. , Dowling, N. Maritza , Johnson, Sterling C.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2339 Get It

Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts
Willette, Auriel A. , Webb, J. L. , Lutz, Michael W. , Bendlin, Barbara B. , Wennberg, Alexandra , Oh, Jennifer M. , Roses, Allen D., Koscik, Rebecca L. , Dowling, N. Maritza , Asthana, Sanjay , Asthana, Sanjay , Wennberg, Alexandra M, Hermann, Bruce P. , Johnson, Sterling C. , Wennberg, Alexandra M V

Alzheimer's & Dementia | May 23, 2017 | Volume: 13 | Issue: 11 | Pages: 1217-1225

10.1016/j.jalz.2017.03.009 Get It

AbstractIntroductionFamily history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly‐T length on memory decline.MethodsFor 912 nonapolipoprotein ε4 middle‐aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 '523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed.ResultsFor FH negative participants, gene‐dose preservation of memory and global cognition was seen for “very long” versus “short” carriers. For FH positive, an opposite gene‐dose decline was seen for very long versus short carriers. Maternal FH was a stronger predictor in aged, but not middle‐aged, participants. Similar gene‐dose effects were seen for the mitochondrial biomarker aspartate aminotransferase.DiscussionThese results may clarify conflicting findings on TOMM40 poly‐T length and AD‐related decline.
IC‐P‐068: Family History Modulates TOMM40's Effect on Alzheimer's Disease Vascular Risk Factors and Neurodegeneration
Webb, J. L. , Roses, Allen D., Willette, Auriel A. , Lutz, Michael W. , Wennberg, Alexandra , Johnson, Sterling C. , Bendlin, Barbara B.

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2016.06.098 Get It

IC‐P‐065: AD Family History in Non‐APOE4S Modulates The Effects of '523 TOMM40 on Neuropathology and Memory Decline
Willette, Auriel A. , Webb, J. L. , Roses, Allen D., Initiative, the Alzheimer's Disease Neuroimaging, Lutz, Michael W. , Wennberg, Alexandra , Johnson, Sterling C. , Bendlin, Barbara B. , Initiative, the Alzheimer's Disease Neuroimaging

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2016.06.095 Get It

P2‐075: Alzheimer's Disease Family History Modulates Effects of '523 TOMM40 on Memory Decline and Medial Temporal Pathology
Willette, Auriel A. , Webb, J. L. , Roses, Allen D., Initiative, Alzheimer's Disease Neuroimaging, Lutz, Michael W. , Wennberg, Alexandra , Johnson, Sterling C. , Bendlin, Barbara B. , Initiative, Alzheimer's Disease Neuroimaging

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_13 | Pages: No page available

10.1016/j.jalz.2016.06.1280 Get It

P3‐079: Alzheimer's Disease Family History Modifies Tomm40 Effects on Vascular Risk Factors and Neurovascular Pathology
Webb, J. L. , Willette, Auriel A. , Lutz, Michael W. , Wennberg, Alexandra

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_17 | Pages: No page available

10.1016/j.jalz.2016.06.1738 Get It