Citations 2
A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork
Loewen, Ralitsa T., Roy, Pritha , Park, Daniel B. , Jensen, Adrianna , Scott, Gordon, Cohen-Karni, Devora , Fautsch, Michael P. , Schuman, Joel S. , Loewen, Nils A. , Schuman, Joel S
Investigative Opthalmology & Visual Science | March 22, 2016 | Volume: 57 | Issue: 3 | Pages: 1338
Heterozygous ATR Mutations in Mismatch Repair–Deficient Cancer Cells Have Functional Significance
Lewis, Kriste A., Mullany, Sally A., Thomas, Bijoy J., Chien, Jeremy , Loewen, Ralitsa T., Shridhar, Viji , Cliby, William A. , Chien, Jeremey
Cancer Research | September 20, 2005 | Volume: 65 | Issue: 16 | Pages: 7091-7095
Abstract ATR (ataxia telangiectasia and Rad3-related) function is necessary for the proper response to commonly used chemotherapeutic agents. Heterozygous truncating mutations in exon 10 of the ATR gene have been described in numerous cancers exhibiting microsatellite instability. We show that truncating mutations of ATR are capable of acting in a dominant-negative manner to abrogate ATR-dependent Chk1 phosphorylation and cell-cycle arrests after DNA damage. In addition, endometrial cell lines harboring ATR mutations are defective for ATR-dependent responses. These findings imply that ATR mutations play an important role in the development and clinical behavior of a subset of microsatellite instability–positive endometrial, colon, and stomach cancers.