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Zhang, Kang

https://orcid.org/0000-0002-4549-1697

Mayo Clinic

Macau University of Science and Technology

Citations 4

Pig-to-human lung xenotransplantation in a brain-dead human recipient
Liu, Xiaoyou , Peng, Guilin, Shi, Jiang , Ju, Chunrong, He, Ping , Liu, Xiaoqing , Zhang, Zuopen, Chen, Chuanbao, Pan, Dengke, Yang, Zifeng , Guan, Wenda, 陈, 中华克劳斯, Liu, Menyang, Liang, Hengrui , Zhao, Yi , Huang, Weiqing , Rucker, A. Justin , Xu, Xin , He, Jianxing , Yang, Chao , Liu, Hui, Liu, Xiaoqing, Zhang, Zuopeng , Pan, Dengke , Yang, Zifeng , Guang, Wenda, Li, Hongtao , Chen, Zhonghua, Liang, Hengrui , Jeon, Kyeongman , Chen-Yoshikawa, Toyofumi Fengshi , Lal, Amos, Zhang, Kang , Zhang, Kang , Liu, Xiaoyou , Xu, Xin

No container title available | November 10, 2024 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.21203/rs.3.rs-5155123/v1 Get It

Abstract This study reports the first pig-to-human lung xenotransplantation using a six gene-edited pig lung. A left lung from a gene-edited Chinese Bama Xiang pig was transplanted into a 39-year-old brain-dead human recipient. The xenograft maintained viability and functionality for 216 hours without signs of hyperacute rejection. Postoperatively, severe edema resembling primary graft dysfunction (PGD) was observed, potentially due to ischemia-reperfusion injury. Antibody-mediated rejection appeared to contribute to xenograft damage on postoperative days 3 and 6, with partial recovery by day 9 under the current immunosuppressive regimen. This pioneering study suggests that genetically modified pig lungs could potentially be used for future clinical applications in xenotransplantation.
Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses
Khawaja, Anthony P. , Bailey, Jessica N. Cooke , Allingham, R. Rand, Hauser, Michael A. , Brilliant, Murray H. , Budenz, Donald L. , Christen, William G. , Fingert, John H. , Gaasterland, Douglas, Gaasterland, Terry , Kraft, Peter , Lee, Richard K., Lichter, Paul R. , Medeiros, Felipe A. , Moroi, Sayoko E. , Richards, Julia E. , Realini, Tony , Schuman, Joel S. , Scott, William K. , Singh, Kuldev, Sit, Arthur J. , Vollrath, Douglas, Wollstein, Gadi , Zhang, Kang , Pericak‐Vance, Margaret A. , Haines, Jonathan L. , Pasquale, Louis R. , Wiggs, Janey L. , Kang, Jae Hee , Liu, Yutao , Ritch, Robert , Zack, Donald J. , Weinreb, Robert Neal , Kraft, Peter , Moroi, Sayoko E , Schuman, Joel S , Sit, Arthur J

Investigative Opthalmology & Visual Science | September 23, 2016 | Volume: 57 | Issue: 11 | Pages: 5046

10.1167/iovs.16-20017 Get It

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium
Bailey, Jessica N. Cooke , Helwa, Inas , Dismuke, W. Michael , Cai, Jingwen , Drewry, Michelle , Brilliant, Murray H. , Budenz, Donald L. , Christen, William G. , Fingert, John H. , Gaasterland, Douglas, Gaasterland, Terry , Gordon, Mae O. , Igo, Robert P. , Kass, Michael A. , Kraft, Peter , Lee, Richard K., Lichter, Paul R. , Moroi, Sayoko E. , Realini, Anthony, Richards, Julia E. , Schuman, Joel S. , Scott, William K. , Singh, Kuldev, Sit, Arthur J. , Song, Yeunjoo E. , Vollrath, Douglas, Medeiros, Felipe A. , Wollstein, Gadi , Zhang, Kang , Pericak‐Vance, Margaret A. , González, Pedro, Kuchtey, John , Kuchtey, Rachel W. , Allingham, R. Rand, Hauser, Michael A. , Pasquale, Louis R. , Haines, Jonathan L. , Wiggs, Janey L. , Liu, Yutao , Chasman, Daniel I. , Kang, Jae Hee , Ritch, Robert , Weinreb, Robert Neal , Zack, Donald J. , Stamer, William Daniel , Kraft, Peter , Moroi, Sayoko E , Schuman, Joel S , Sit, Arthur J

Investigative Opthalmology & Visual Science | August 15, 2016 | Volume: 57 | Issue: 10 | Pages: 4528

10.1167/iovs.16-19688 Get It

Pharmacogenomics of Response to Anti-VEGF Therapy in Exudative Age-Related Macular Degeneration
Grob, Seanna, Zhang, Kang , Bakri, Sophie J.

Ophthalmic Disease Mechanisms and Drug Discovery | August 10, 2016 | Volume: No volume available | Issue: No issue available | Pages: 63-95

10.1142/9789814663076_0004 Get It