Citations 2
Circulating plasma cells detected by flow cytometry as a predictor of survival in patients with newly diagnosed multiple myeloma
Nowakowski, Grzegorz S. , Greipp, Philip R., Witzig, Thomas E. , Dingli, David , Tracz, Michał , Rajkumar, S. Vincent
Journal of Clinical Oncology | February 23, 2017 | Volume: 23 | Issue: 16_suppl | Pages: 6580-6580
Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma
Nowakowski, Grzegorz S. , Dingli, David , Lacy, Martha Q. , Lust, John A., Dispenzieri, Angela , Greipp, Philip R., Kyle, Robert A. , Rajkumar, S. Vincent , Witzig, Thomas E. , Tracz, Michał , Gertz, Morie A. , Rajkumar, S Vincent , Dispenzieri, Angela , Dingli, David
Blood | June 16, 2005 | Volume: 106 | Issue: 7 | Pages: 2276-2279
Abstract We detected circulating plasma cells (PCs) by flow cytometry in 302 patients with newly diagnosed multiple myeloma (MM) by gating on CD38+CD45- cells. The number of circulating PCs per 50 000 mononuclear cells was reported. In 80 (27%) patients, no circulating PC were seen; 106 (35%) patients had 1 to 10 and 115 (38%) patients had more than 10 circulating PCs. Median overall survival for the 302 patients was 47 months. Patients with 10 or fewer circulating PCs had a median survival of 58.7 months, whereas patients with more than 10 circulating PCs had a median survival of 37.3 months (P = .001). On multivariate analysis, the prognostic value of circulating PCs was independent of β2-microglobulin, albumin, and C-reactive protein. There was only a weak correlation between tumor mass and circulating PCs, suggesting that the appearance of circulating PCs may be a reflection of tumor biology. We conclude that the number of circulating PCs measured by flow cytometry in patients with newly diagnosed MM is an independent predictor of survival.