Citations 1
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice
Zhang, Zubin , Tong, Jiefei , Tang, Xiaowen , Juan, Jiaxiang , Cao, Biyin, Hurren, Rose, Chen, Guodong , Taylor, Paul , Xu, Xin , Shi, Chang-Xin, Hou, Jian , Wang, Guanghui , Stewart, A. Keith, Schimmer, Aaron D. , Mao, Xinliang , Chen, Guodong, Du, Juan , Wu, Depei , Moran, Michael F.
Blood | January 30, 2016 | Volume: 127 | Issue: 13 | Pages: 1676-1686
Key Points HERC4 is the first identified ubiquitin ligase that mediates c-Maf ubiquitination and degradation. HERC4 suppresses MM cell proliferation and delays MM tumor growth.