Citations 1
Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
Albayati, Zaineb A.F., Sunkara, Manjula , Schmidt-Malan, Suzannah M., Karau, Melissa J. , Morris, Andrew J. , Steckelberg, James M., Patel, Robin , Breen, Philip J., Smeltzer, Mark S. , Taylor, K. Grant, Merten, Kevyn E., Pierce, William M., Crooks, Peter A. , Patel, Robin
Antimicrobial Agents and Chemotherapy | December 15, 2015 | Volume: 60 | Issue: 3 | Pages: 1865-1868
ABSTRACT We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.