Ruzhansky, Katherine
https://orcid.org/0000-0001-7234-3254
Mayo Clinic
Medical University of South Carolina
Citations 4
Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis
Clifford, Katherine , Hobson‐Webb, Lisa D., Benatar, Michael , Burns, Ted M., Barnett, Carolina , Silvestri, Nicholas J. , Howard, James F. , Visser, Amy , Beekman, Rachel , Kumar, Aditya , Ruzhansky, Katherine , Chen, I-Hweii A. , Pulley, Michael , LaBoy, Shannon, Fellman, Melissa, Howard, Diantha B., Kolb, Noah , Greene, Shane M., Pasnoor, Mamatha , Dimachkie, Mazen M. , Hehir, Michael K. , Kumar, Aditya , Clifford, Katherine M , Crum, Brian A. , Kolb, Noah A , Dimachkie, Mazen M , Barnett-Tapia, Carolina , Nowak, Richard J. , Barohn, Richard J. , Beekman, Rachel B
Muscle & Nerve | December 21, 2018 | Volume: 59 | Issue: 4 | Pages: 404-410
ABSTRACT Introduction : A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)‐antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious in anti–muscle‐specific kinase (MuSK)‐MG. Methods : The therapeutic impact of thymectomy was evaluated from data collected for a multicenter, retrospective blinded review of rituximab in MuSK‐MG. Results : Baseline characteristics were similar between thymectomy ( n = 26) and nonthymectomy ( n = 29) groups, including treatment with rituximab (42% vs. 45%). At last visit, 35% of thymectomy subjects reached the primary endpoint, a Myasthenia Gravis Foundation of America (MGFA) post‐intervention status (PIS) score of minimal manifestations (MM) or better, compared with 55% of controls ( P = 0.17). After controlling for age at onset of MG, rituximab, prednisone, and intravenous immunoglobulin/plasma exchange treatment, thymectomy was not associated with greater likelihood of favorable clinical outcome (odds ratio = 0.43, 95% confidence interval 0.12–1.53, P = 0.19). Discussion : Thymectomy was not associated with additional clinical improvement in this multicenter cohort of MuSK‐MG patients. Muscle Nerve 59:404–410, 2019
Rituximab as treatment for anti-MuSK myasthenia gravis
Hehir, Michael K. , Hobson‐Webb, Lisa D., Benatar, Michael , Silvestri, Nicholas J. , Howard, James F. , Howard, Diantha B., Visser, Amy , Beekman, Rachel , Kumar, Aditya , Ruzhansky, Katherine , Chen, I-Hweii A. , Pulley, Michael , LaBoy, Shannon, Fellman, Melissa, Greene, Shane M., Pasnoor, Mamatha , Burns, Ted M., Kumar, Aditya , Barnett, Carolina , Howard, Diantha, Crum, Brian A. , Nowak, Richard, Chen, I-Hweii Amy, Pulley, Michael T, LaBoy, Shannon M, Fellman, Melissa A, Nowak, Richard J. , Beekman, Rachel B
Neurology | August 11, 2017 | Volume: 89 | Issue: 10 | Pages: 1069-1077
Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial
Dyck, Peter J., Dyck, Peter J., Kincaid, John C., Dyck, P. James B. , Chaudhry, Vinay , Goyal, Namita , Alves, Christina , Salhi, Hayet, Wiesman, Janice F. , Labeyrie, Céline , Robinson‐Papp, Jessica , Cardoso, Márcio , Laurá, Matilde , Ruzhansky, Katherine , Cortese, Andrea , Brannagan, Thomas H., Khoury, Julie, Khella, Sami, Ferreira, João , Wang, Annabel K., Pinto, Marcus Vinícius , Ayache, Samar S. , Benson, Merrill D., Coelho, Teresa , Polydefkis, Michael , Gorevic, Peter D., Planté‐Bordeneuve, Violaine , Whelan, Carol , Merlini, Giampaolo , Drachman, Brian, Conceição, Isabel , Klein, Christopher J. , Ackermann, Elizabeth J., Hughes, Steven G. , Mauermann, Michelle L. , Bergemann, R , Lodermeier, Karen A., Davies, Jenny L., Carter, Rickey E. , Litchy, William J. , Dyck, Peter J., Dyck, Peter J., Waddington‐Cruz, Márcia , Berk, John L. , Adams, David , Heitner, Stephen B. , Gertz, Morie A. , Merlini, Giampaolo , Pinto, Marcus V , Klein, Christopher J , Brannagan, T H , Carter, Rickey E , Conceição, Isabel , Mauermann, Michelle L
Muscle & Nerve | January 7, 2017 | Volume: 56 | Issue: 5 | Pages: 901-911
ABSTRACTIntroductionPolyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic tests (m+7Ionis), disability, and health scores were assessed in baseline evaluations of 100 patients entered into an oligonucleotide familial amyloidotic polyneuropathy (FAP) trial.MethodsWe assessed: (1) Proficiency of grading neurologic signs and correlation with neurophysiologic tests, and (2) clinometric performance of modified NIS+7 neurophysiologic tests (mNIS+7Ionis) and its subscores and correlation with disability and health scores.ResultsThe mNIS+7Ionis sensitively detected, characterized, and broadly scaled diverse polyneuropathy impairments. Polyneuropathy signs (NIS and subscores) correlated with neurophysiology tests, disability, and health scores. Smart Somatotopic Quantitative Sensation Testing of heat as pain 5 provided a needed measure of small fiber involvement not adequately assessed by other tests.ConclusionsSpecially trained neurologists accurately assessed neuropathy signs as compared to referenced neurophysiologic tests. The score, mNIS+7Ionis, broadly detected, characterized, and scaled polyneuropathy abnormality in FAP, which correlated with disability and health scores. Muscle Nerve 56: 901–911, 2017
Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine
Burns, Ted M., Smith, Gordon, Allen, Jeffrey A. , Amato, Anthony A. , Arnold, W. David , Barohn, Richard J., Benatar, Michael , Bird, Shawn J. , Bromberg, Mark B. , Chahin, Nizar, Ciafaloni, Emma , Corse, Andrea M. , David, William S., Dimberg, Elliot L., Sousa, De , Donofrio, Peter D., Dyck, P. James B. , Engel, Andrew G. , Ensrud, Erik , Ferrante, Mark A., Freimer, Miriam , Gable, Karissa , Gibson, Summer, Gilchrist, James M. , Goldstein, Jonathan , Gooch, Clifton L. , Goodman, Brent P., Gorelov, Dmitri, Gospe, Sídney M. , Goyal, Namita , Guidon, Amanda C. , Guptill, Jeffrey T. , Gutmann, Laurie , Gutmann, Ludwig , Gwathmey, Kelly , Harati, Yadollah, Harper, C. Michel , Hehir, Michael K. , Hobson‐Webb, Lisa D., Howard, James F. , Jackson, Carlayne E. , Jones, Sarah , Juel, Vern C. , Kaminski, Henry J. , Kennelly, Kathleen D., Khella, Sami, Khoury, Julie, Kincaid, John C., Kissel, John T., Kolb, Noah , Lacomis, David , Larriviere, Daniel G., Lewis, Richard A. , Litchy, William J. , Logigian, Eric L. , Lou, Jau-Shin, MacGowen, Daniel J.L., Maselli, Ricardo A. , Massey, Janice M., Mauermann, Michelle L. , Mathews, Katherine D. , Meriggioli, Matthew N. , Moon, Joon-Shik, Mozaffar, Tahseen , Nations, Sharon , Ostrow, Lyle W. , Pascuzzi, Robert M. , Peltier, Amanda , Ruzhansky, Katherine , Ross, Mark A., Rubin, Devon I., Russell, James A., Sachs, George, Salajegheh, Mohammad, Saperstein, David , Scelsa, Stephen N. , Selcen, Duygu , Shaibani, Aziz , Silvestri, Nicholas J. , Singleton, J. Rob, Smith, Benn E., So, Yuen T., Solórzano, Guillermo, Sorenson, Eric J. , Srinivasen, Jayashri, Tavee, Jinny , Tawil, Rabi , Thaisetthawatkul, Pariwat , Thornton, Charles A. , Trivedi, Jaya , Vernino, Steven , Wang, Annabel K., Webb, Tyler A., Weiss, Michael D. , Windebank, Anthony J. , Wolfe, Gil I. , Crum, Brian A. , Dimberg, Elliot, Chahin, Nizar, Cohen, Jeffrey Allen , Johnson, Nicholas E , Karam, Chafic , Ladha, Shafeeq , Li, Yuebing , Miller, Robert G. , Nowak, Richard J. , Richman, David P. , Shieh, Perry B. , Kolb, Noah A , Mauermann, Michelle L , Gutmann, Laurie , Allen, Jeffrey A , Arnold, W David , Vernino, Steven , Kaminski, Henry
Muscle & Nerve | December 13, 2015 | Volume: 53 | Issue: 2 | Pages: 165-168