Citations 1
In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli
Cunningham, Scott A. , Cole, Nicolynn C., Kohner, Peggy C., Menon, Sanjay , Krause, Kevin M. , Harris, Kelly , De, Partha Pratim, Koh, Tse Hsien , Patel, Robin , Vasoo, Shawn , Patel, Robin , Cunningham, Scott A
Antimicrobial Agents and Chemotherapy | September 22, 2015 | Volume: 59 | Issue: 12 | Pages: 7842-7846
ABSTRACT Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.