Citations 1
Heritability of young‐ and old‐onset ischaemic stroke
Bluher, Andrew E. , Devan, William J., Holliday, E. G., Nalls, Mike A. , Parolo, Silvia , Bione, Silvia , Giese, Anne‐Katrin , Boncoraglio, Giorgio B. , Maguire, Jane , Müller‐Nurasyid, Martina , Gieger, Christian , Rolfs, A., Kittner, Steven J. , Mitchell, Braxton D. , O’Connell, Jeff, Holliday, E. G., Meschia, James F. , Rosand, Jonathan M. , Cheng, Y.‐C., Mitchell, Braxton D
European Journal of Neurology | September 3, 2015 | Volume: 22 | Issue: 11 | Pages: 1488-1491
Background and purposeAlthough the genetic contribution to stroke risk is well known, it remains unclear if young‐onset stroke has a stronger genetic contribution than old‐onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole‐genome array data in population‐based samples.MethodsThis analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young‐onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole‐genome array data using a mixed linear model. Heritability was estimated separately for young‐onset stroke and old‐onset stroke (age ≥ 55 years).ResultsHeritabilities for young‐onset stroke and old‐onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively.ConclusionsOur data suggest that the genetic contribution to the risk of stroke may be higher in young‐onset ischaemic stroke, although the difference was not statistically significant.