Citations 1
Ventilator-induced lung injury: in vivo and in vitro mechanisms
Matthay, Michael A. , Bhattacharya, Sunita , Gaver, Donald P. , Ware, Lorraine B. , Syrkina, Olga, Eyal, Fabien, Hubmayr, Rolf D., Lim, Lina H. K.
American Journal of Physiology-Lung Cellular and Molecular Physiology | March 3, 2015 | Volume: 283 | Issue: 4 | Pages: L678-L682
A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.