Wu, Zhidan

Mayo Clinic

Novartis Institutes for Biomedical Research, Cambridge, MA 02139; and

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, James P. , Wrann, Christiane D. , Rao, Rajesh R., Nair, Sreekumaran K., Jedrychowski, Mark P., You, Jae‐Sung , Martínez-Redondo, Vicente, Gygi, Steven P. , Ruas, Jorge L. , Hornberger, Troy A. , Wu, Zhidan , Glass, David J. , Piao, Xianhua , Spiegelman, Bruce M. , Nair, Sreekumaran K.

Proceedings of the National Academy of Sciences | October 22, 2014 | Volume: 111 | Issue: 44 | Pages: 15756-15761

Significance The work reported in this paper describes a previously unknown signaling pathway in skeletal muscle acting through G protein-coupled receptor 56-Galpha12/13. This discovery elucidates a previously unknown mechanism of muscle anabolism and gives another target of investigation for therapies against the loss of muscle mass seen with aging and various wasting diseases.

Wu, Zhidan

Citations 1

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, James P. , Wrann, Christiane D. , Rao, Rajesh R., Nair, Sreekumaran K., Jedrychowski, Mark P., You, Jae‐Sung , Martínez-Redondo, Vicente, Gygi, Steven P. , Ruas, Jorge L. , Hornberger, Troy A. , Wu, Zhidan , Glass, David J. , Piao, Xianhua , Spiegelman, Bruce M. , Nair, Sreekumaran K.