Citations 2
Dilated Form of Endocardial Fibroelastosis as a Result of Deficiency in Respiratory-Chain Complexes I and IV
Corradi, Domenico , Tchana, Bertrand , Miller, Dylan V. , Manotti, Laura, Maestri, Roberta, Martorana, Davide , Callegari, Sergio , Allegri, V., Carano, N., Agnetti, A., Squarcia, Umberto
Circulation | August 11, 2009 | Volume: 120 | Issue: 6 | Pages: No page available
Acute Myocardial Infarction in a Child: Possible Pathogenic Role of Patent Foramen Ovale Associated With Heritable Thrombophilia
Carano, Nicola, Agnetti, A., Hagler, Donald J. , Tchana, Bertrand , Squarcia, Umberto, Bernasconi, Sergio
Pediatrics | August 14, 2004 | Volume: 114 | Issue: 2 | Pages: e255-e258
We report an 8-year-old girl who presented with clinical features of an acute myocardial infarction. The angiographic appearance of the coronary arteries was normal. A thrombophilic state caused by a homozygote genotype for the prothrombin G20210A mutation was detected, and a patent foramen ovale (PFO) with right-to-left shunting after Valsalva maneuver was demonstrated by transesophageal contrast echocardiography. No other embolic source was identified. We suggest that paradoxical embolization through a PFO resulted in a myocardial infarction in this young patient with hereditary thrombophilia. We closed the patient’s PFO with a 25-mm PFO occluder. She was anticoagulated with warfarin for 6 months. After 6 months, a contrast echocardiogram showed no evidence of residual atrial shunt. There has been no evident recurrent paradoxical embolization.