Citations 1
CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma
Murray, Megan , Gavile, Catherine M., Koorella, Chandana, Carlson, Louise, Buac, Daniela, Utley, Adam, Chesi, Marta , Bergsagel, P. Leif , Boise, Lawrence , Lee, Kelvin P. , Bergsagel, P. Leif , Lee, Kelvin P , Nair, Jayakumar R. , Boise, Lawrence H
Blood | April 30, 2014 | Volume: 123 | Issue: 24 | Pages: 3770-3779
Key PointsCD28 delivers a pro-survival signal to MM cells via regulation of PI3K/Akt, FoxO3a, and Bim. Blockade of CD28:CD80/CD86 in vivo resensitizes MM cells to chemotherapy and significantly reduces tumor burden.