Citations 2
Normothermic regional perfusion (NRP) use in controlled donation after circulatory determination of death (cDCDD): results of the European Society for Organ Transplantation Bucharest consensus conference
Cruz, José Luis Campo-Cañaveral de la , Croome, K, Feltrin, Giuseppe, Hessheimer, Amelia, Messer, Simon, Wall, Anji, Domínguez-Gil, Beatriz, Martin, Dominique, Oniscu, Gabriel, Cillo, Umberto, Miñambres, Eduardo , Berman, Marius , Antonini, Marta Velia , Croome, Kristopher P. , Feltrin, Giuseppe , Hessheimer, Amelia J. , Jorns, Carl , Domínguez‐Gil, Beatriz , Martin, Dominique , Oniscu, Gabriel C. , Cillo, Umberto
Transplant International | July 22, 2026 | Volume: 39 | Issue: No issue available | Pages: No page available
Normothermic Regional Perfusion (NRP) is emerging as a game-changer in enhancing outcomes for Donation after Circulatory Determination of Death (DCDD). NRP maintains physiological conditions through perfusion with oxygenated blood, outperforming conventional super-rapid recovery techniques significantly improving outcomes and organ utilization. Despite its clinical benefits, widespread adoption of NRP is impeded by heterogeneous organizational, legal, and ethical frameworks. At the ESOT Bucharest Consensus Conference, leading experts in transplantation achieved consensus on 130 relevant NRP-related open issues to facilitate its implementation and guide global practice. Key recommendations include criteria for adoption of NRP, minimal requirements, procedures to be adopted before and during NRP, donor organ evaluation criteria and sequence of organ harvesting. Consensus extends to procedural components (including the configuration of perfusion parameters and strategic team coordination), ethical integrity of NRP in the context of the dead donor rule and key unmet needs for future developments. While significant strides were made in unifying practice, unresolved issues regarding maximum warm ischemic time and variability in legal standards indicate avenues for future research. This consensus underscores the imperative for global standardization in NRP application, promising to elevate the success rates of organ transplants and establish NRP as a foundational element in the evolution of DCDD.
Contemporary extracorporeal cardiopulmonary resuscitation programs for cardiac arrest
Bugo, Samuele , Ursoleo, Jacopo D’Andria, Cordella, Erika , Aprile, Myriam, Garcia, S I, Elmadhoun, Omar, Wieruszewski, Erin D. , Swol, Justyna, Wieruszewski, Patrick M., Monaco, F Roversi, Garcia, Samuel I. , Bottussi, Alice , Ursoleo, Jacopo D’Andria , Antonini, Marta Velia , Elmadhoun, Omar, Swol, Justyna , Wieruszewski, Patrick M.
Frontiers in Cardiovascular Medicine | July 8, 2026 | Volume: 13 | Issue: No issue available | Pages: No page available
Cardiac arrest is a leading cause of global mortality, with low survival rates despite advances in resuscitation science. Reported survival ranges from 8% to 34% for out-of-hospital and in-hospital cardiac arrest. Extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as a rescue therapy for patients unresponsive to conventional CPR, leveraging veno-arterial extracorporeal membrane oxygenation (ECMO) to provide artificial circulation, gas exchange, and maintenance of organ perfusion in the absence of spontaneous native circulation. Successful ECPR depends on minimizing time to ECMO initiation and selecting appropriate patients. While several aspects are consistent across countries, ECPR protocols vary in logistics, team composition, cannulation methods, and monitoring, which may influence patient-important outcomes such as survival and neurological recovery. This narrative review explores current global practices in ECPR, and identifies opportunities for standardization while recognizing elements that should remain context specific.