Citations 1
Network Reorganization of Anterograde Thalamic Connectivity During Non-Periodic Patterned Deep Brain Stimulation
Johnson, Teryn D. , Mohan, Bobby, Cramer, Justin , Drees, Cornelia , Hoerth, Matthew T., Crepeau, Amy Z. , Drazkowski, Joseph F., Baxter, Leslie, Harris, Christopher, Ince, Nuri F. , Miller, Kai, Hermes, dora, Worrell, Gregory, Parker, Jonathon J. , Baxter, Leslie C. , Baxter, Leslie C. , Huang, Harvey, Cramer, Justin, Drees, Cornelia , Drazkowski, Joseph, Noe, Katherine H. , Mbonde, Amir A. , Miller, Kai, Hermes, Dora , Worrell, Gregory
No container title available | January 28, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
ABSTRACT Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) can reduce seizures in patients with drug-resistant epilepsy. However, seizure freedom is rare, and there is no early response biomarker to predict long-term seizure suppression. To evaluate a short-term biomarker of therapeutic response to DBS, we studied 18-minute trials of ANT stimulation in patients with drug-resistant epilepsy undergoing intracranial electroencephalography. We compared a standard high-frequency periodic versus a non-periodic pulse pattern. We found that short-term ANT stimulation within the clinically used amplitude range preferentially altered the first 150 ms of anterograde ANT to anterior cingulate and superior frontal connectivity. Non-periodic ANT stimulation selectively modified early cortico-cortical evoked potentials more than periodic stimulation, and these changes were driven by the response phase. These pattern-specific changes in connectivity between the ANT and spatially restricted cortical areas suggest differing mechanisms and are a promising biomarker for patients being treated with ANT-DBS.