Abstract The sections in this article are: Vascular Anatomy and Fluid Phase Conduit Vessels to Bone Capillaries of Bone Fluid Transport Physiological Implications Bone Tissue Turnover Bone Remodeling Cells of Bone Mineral Phase Bone Repair Transport of Ions and Molecules in Bone Movement Into Bone From Bulk Extracellular Fluid (Influx) Efflux Methodology Indicator‐Dilution Methods Steady‐State Techniques (Volume of Distribution) Blood Flow Summary and Conclusions