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Fischer, Elizabeth R.

https://orcid.org/0000-0002-3292-3673

Mayo Clinic

National Institutes of Health

Citations 2

Automatic Path-Planning Techniques for Minimally Invasive Stereotactic Neurosurgical Procedures—A Systematic Review
Monfaredi, Reza , Concepcion-Gonzalez, Alondra, Julbe, Jose Acosta, Fischer, Elizabeth R. , Hernandez-Herrera, Gabriel, Concepción-González, Alondra , Julbe, José I Acosta , Fischer, Elizabeth, Hernandez-Herrera, Gabriel A. , Cleary, Kevin , Oluigbo, Chima

Sensors | August 13, 2024 | Volume: 24 | Issue: 16 | Pages: 5238

10.3390/s24165238 Get It

This review systematically examines the recent research from the past decade on diverse path-planning algorithms tailored for stereotactic neurosurgery applications. Our comprehensive investigation involved a thorough search of scholarly papers from Google Scholar, PubMed, IEEE Xplore, and Scopus, utilizing stringent inclusion and exclusion criteria. The screening and selection process was meticulously conducted by a multidisciplinary team comprising three medical students, robotic experts with specialized knowledge in path-planning techniques and medical robotics, and a board-certified neurosurgeon. Each selected paper was reviewed in detail, and the findings were synthesized and reported in this review. The paper is organized around three different types of intervention tools: straight needles, steerable needles, and concentric tube robots. We provide an in-depth analysis of various path-planning algorithms applicable to both single and multi-target scenarios. Multi-target planning techniques are only discussed for straight tools as there is no published work on multi-target planning for steerable needles and concentric tube robots. Additionally, we discuss the imaging modalities employed, the critical anatomical structures considered during path planning, and the current status of research regarding its translation to clinical human studies. To the best of our knowledge and as a conclusion from this systematic review, this is the first review paper published in the last decade that reports various path-planning techniques for different types of tools for minimally invasive neurosurgical applications. Furthermore, this review outlines future trends and identifies existing technology gaps within the field. By highlighting these aspects, we aim to provide a comprehensive overview that can guide future research and development in path planning for stereotactic neurosurgery, ultimately contributing to the advancement of safer and more effective neurosurgical procedures.
Activated mouse eosinophils protect against lethal respiratory virus infection
Percopo, Caroline M. , Dyer, Kimberly D., Ochkur, Sergei I. , Luo, Janice L., Fischer, Elizabeth R. , Lee, James J. , Lee, Nancy A., Domachowske, Joseph B. , Rosenberg, Helene F.

Blood | December 2, 2013 | Volume: 123 | Issue: 5 | Pages: 743-752

10.1182/blood-2013-05-502443 Get It

Key Points Eosinophils recruited to the airways in response to A fumigatus sensitization and challenge degranulate in response to virus infection. Activated eosinophils are antiviral and promote survival from an otherwise lethal respiratory virus infection.