Alayash, Abdu I.

Mayo Clinic

Center for Biologics Evaluation and Research

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, John D. , Chen, Chunsheng , Nguyen, Julia , Milbauer, Liming , Abdulla, Fuad , Alayash, Abdu I. , Smith, Ann , Nath, Karl A. , Hebbel, Robert P. , Vercellotti, Gregory M.

Blood | November 26, 2013 | Volume: 123 | Issue: 3 | Pages: 377-390

10.1182/blood-2013-04-495887

Key Points Heme, released from hemoglobin, elicits vaso-occlusion in transgenic sickle mice via endothelial TLR4 signaling. Heme/TLR4 signaling activates NF-κB and triggers vaso-occlusion through Weibel-Palade body degranulation and adhesion molecule expression.

Alayash, Abdu I.

Citations 1

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, John D. , Chen, Chunsheng , Nguyen, Julia , Milbauer, Liming , Abdulla, Fuad , Alayash, Abdu I. , Smith, Ann , Nath, Karl A. , Hebbel, Robert P. , Vercellotti, Gregory M.