Citations 1
(103) Prior Intracavernosal Injection Therapy and Prostate Cancer Treatment are Both Independently Associated with Increased Risks of Complications in Men Undergoing Inflatable Penile Prosthesis Placement
Hammad, Muhammed , Barham, David W. , Swerdloff, Daniel , Miller, Justin , Andrianne, Robert, Gross, Kelli, Hatzichristodoulou, G, Hotaling, James M. , Hsieh, T.‐C., Jones, Adam , Lentz, A, Modgil, Vaibhav , Osmonov, Daniar , Park, S H , Pearce, Ian , Perito, Paul , Sadeghi‐Nejad, Hossein , Sempels, Maxime, Suarez‐Sarmiento, Alfredo, Simhan, J, Warner, J, Ziegelmann, Matthew , Yafi, Faysal A. , collaborators, on behalf of the PUMP (Prosthetic Urology Multi-institutional Partnership), Hammad, Muhammed A M , Jones, J M, Gross, Martin , Chang, Chun‐Chao , Burnett, Arthur L. “Bud” , Hatzichristodoulou, Georgios , Lentz, A, Simhan, Jay , Renterghem, Koenraad van , collaborators, on behalf of the PUMP (Prosthetic Urology Multi-institutional Partnership)
The Journal of Sexual Medicine | March 5, 2024 | Volume: 21 | Issue: Supplement_2 | Pages: No page available
Abstract Introduction Intracavernosal injection (ICI) therapy for erectile dysfunction (ED) carries a risk of corporal fibrosis, potentially making placement of an inflatable penile prosthesis more difficult. Prostate cancer treatment may also induce corporal fibrosis. Objective To assess whether a history of ICI or prostate cancer treatment is associated with complications following IPP placement. Methods A retrospective cohort study of primary IPP cases from 2016–2021 across 16 institutions. Patients were stratified by history of ICI and between-group differences in risk factors were assessed. Multivariable logistic regression was used to assess for predictors of intraoperative complications, postoperative non-infectious complications and postoperative infection. Results A total of 2540 patients met inclusion criteria of which 781 (30.8%) had a history of ICI. Patients with a history of ICI tended to be older (mean 63 vs 64 years, p=0.002) and were more likely to have history of radical prostatectomy (21.0% vs. 32.1%, p<0.001) and/or radiation (5.51% vs 10.9%, p<0.001). On multivariable regression, a history of ICI, prostatectomy, and radiation were all significant predictors of intraoperative complications (OR 2.11, p=0.03; OR 2.27, p=0.03; OR 2.40, p=0.04, respectively). A history of ICI and patient age were predictors of non-infectious postoperative complications (OR 1.44, p=0.02, OR 1.02, p=0.004 respectively)). None of the variables were significant predictors of infection. Conclusions In men undergoing IPP placement, a history of ICI is associated with an increased risk of both intraoperative and postoperative, non-infectious complications. Prostate cancer treatment with radiation or surgery is independently associated with increased risk of intraoperative complications. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: D.O. has served as a consultant for Coloplast, Intuitive Surgical, and Fidelis. P.P. has served as a consultant for Coloplast, Boston Scientific, and Urofill. M.S. has served as a consultant for Boston Scientific and Coloplast. J.S. has served as a consultant for Boston Scientific and Coloplast. F.A.Y. has served as a consultant for Coloplast, Cynosure, Antares Pharma, Clarus Pharmaceuticals, and Acerus Pharma. M.S.G. has served as a consultant for Coloplast. The other authors disclose no conflicts.