Citations 1
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1
Laval, Bérengère de , Pawlikowska, Patrycja , Barbieri, Daniela , Besnard‐Guérin, Corinne , Cico, Alba, Kumar, Rajiv , Gaudry, Muriel , Baud, Véronique , Porteu, Françoise , Kumar, Rajiv
Blood | November 2, 2013 | Volume: 123 | Issue: 4 | Pages: 509-519
Key Points TPO specifically activates Erk and NF-κB pathways in hematopoietic stem and progenitor cells. Erk and NF-κB cooperate to trigger their common target, Iex-1, and DNA-PK-dependent NHEJ activation in HSPCs upon irradiation.